Fluorescence molecular tomography (FMT) is a promising tool for real time in vivo quantification of neurotransmission (NT) as we pursue in our BRAIN initiative effort. However, the acquired image data are noisy and the reconstruction problem is ill-posed. Further, while spatial sparsity of the NT effects could be exploited, traditional compressive-sensing methods cannot be directly applied as t...

In this paper, we investigated a C-arm tomographic technique as a new three dimensional (3D) kidney imaging method for nephrolithiasis and kidney stone detection over view angle less than 180o. Our C-arm tomographic technique provides a series of two dimensional (2D) images with a single scan over 40o view angle. Experimental studies were performed with a kidney phantom that was formed from a p...

Introduction: The main goal of SPECT imaging is to determine activity distribution inside the organs of the body. However, due to photon attenuation, it is almost impossible to do a quantitative study. In this paper, we suggest a mathematical relationship between activity distribution and its corresponding projections using a transfer matrix. Monte Carlo simulation was used to find a precise tr...

The small-animal High-Resolution SPECT (HiReSPECT) is a dedicated dual-head gamma camera recently designed and developed in our laboratory for imaging of murine models. Each detector is composed of an array of 1.2 × 1.2 mm(2) (pitch) pixelated CsI(Na) crystals. Two position-sensitive photomultiplier tubes (H8500) are coupled to each head's crystal. In this paper, we report on a resolution-recov...

Introduction: There has been a curiosity about the spheroid geometry for PET scanners developments since several years ago, therefore in this study, we are aiming to evaluate the performance of this geometry and compare its performance with cylindrical geometry using Monte Carlo simulation. Methods: We simulated a spheroid geometry with a radius of 199 mm...

Tomographic imaging with radionuclides commonly used in nuclear medicine, such as $^{111}$In (171 and 245 keV) $^{131}$I (364 keV), is high demand for medical applications small animal imaging. The Si/CdTe Compton camera its angular energy resolutions an especially promising detector to extend the coverage range that covers gamma-ray emitted from these radionuclides. Here, we take first steps t...