نتایج جستجو برای: mixed micelles

تعداد نتایج: 228268  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1979
P Douzou E Keh C Balny

Amphiphilic compounds dissolved in nonpolar organic solvents form inverted micelles whose aqueous centers can solubilize relatively large amounts of enzymes. The solutions are homogeneous and optically transparent and have low viscosity and freezing points; they provide unique and favorable systems to perform the main cryoenzymologic studies previously carried out in mixed solvents. The prepara...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2008
Fumihiko Kitagawa Takayuki Hasegawa Hiromi Taji Satomi Onoue Yoshiko Tsuda Koji Otsuka

In this study, micelles prepared from distearoylphosphatidylethanolamine with covalently attached poly(ethylene) glycol) (PEG) of molecular weight 2000 (DSPE-PEG-2000) were employed in micellar electrokinetic chromatography (MEKC) as pseudostationary phases. Since DSPE-PEG-2000 contains long hydrophobic alkyl chains, an anionic phosphate group, and hydrophilic PEG chains, the prepared micelles ...

2016
Takahiro Harigae Kiyotaka Nakagawa Taiki Miyazawa Nao Inoue Fumiko Kimura Ikuo Ikeda Teruo Miyazawa

PURPOSE Curcumin (CUR), the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. Poly-(lactic-co-glycolic acid)-based CUR nanoparticles (CUR-NP) have recently been suggested to improve CUR bioavailability, but this has not been fully verified. Specifically, no data are available about curcumin glucuro...

2017
Yan Di Ting Li Zhihong Zhu Fen Chen Lianqun Jia Wenbing Liu Xiumei Gai Yingying Wang Weisan Pan Xinggang Yang

The aim of this study was to simultaneously introduce pH sensitivity and folic acid (FA) targeting into a micelle system to achieve quick drug release and to enhance its accumulation in tumor cells. Paclitaxel-(+)-α-tocopherol (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene glycol) methyl ether-poly(histidine) (MPEG-PHIS) and folic acid-poly(ethylene glycol)-(+)-α-tocoph...

2017
Cédric Montigny Thibaud Dieudonné Stéphane Orlowski José Luis Vázquez-Ibar Carole Gauron Dominique Georgin Sten Lund Marc le Maire Jesper V Møller Philippe Champeil Guillaume Lenoir

Membrane proteins are largely dependent for their function on the phospholipids present in their immediate environment, and when they are solubilized by detergent for further study, residual phospholipids are critical, too. Here, brominated phosphatidylcholine, a phospholipid which behaves as an unsaturated phosphatidylcholine, was used to reveal the kinetics of phospholipid exchange or transfe...

Journal: :The Journal of biological chemistry 1989
M H Lee R M Bell

The specificity of the phospholipid cofactor requirement of rat brain protein kinase C was investigated using Triton X-100 mixed micellar methods. Sixteen analogues of phosphatidylserine were prepared and tested for their ability to support protein kinase C activity, [3H]phorbol 12,13-dibutyrate binding, and protein kinase C binding to mixed micelles. Phosphatidylserinol, -L-serine methyl ester...

Journal: :Biochemistry 2000
J K Nagy F W Lau J U Bowie C R Sanders

This work represents the first stage of thiol-based cross-linking studies to map the oligomeric interface of the homotrimeric membrane protein diacylglycerol kinase (DAGK). A total of 53 single-cysteine mutants spanning DAGK's three transmembrane segments and the first part of a cytoplasmic domain were purified and subjected to catalytic oxidation in mixed micelles. Four mutants (A52C, I53C, A7...

Journal: :The Journal of chemical physics 2005
Geuorgui K Bourov Aniket Bhattacharya

We investigate micelle formation in a system containing two or more different amphiphiles with different geometries using a stochastic molecular-dynamics (MD) simulation method. For a binary system containing two amphiphiles, we calculate the critical micelle concentration (CMC) and cluster distribution for the mixture at several mole fractions and compare the simulation results with those pred...

2013
Chun-Chia Cheng Chiung-Fang Huang Ai-Sheng Ho Cheng-Liang Peng Chun-Chao Chang Fu-Der Mai Ling-Yun Chen Tsai-Yueh Luo Jungshan Chang

Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric micelles were designed and manufactured for nucl...

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