this work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1h-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-fe2o3 nanoparticles. eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily availa...

Sequential or simultaneous leukocyte kinetic studies using radioactive diisopropylfluorophosphate and radiochromate (31Cr) yielded similar or identical blood leukocyte disappearance curves in seven patients with chronic myelocytic leukemia (CML). Body surface counting regularly showed a rise in the spleen counting rate during the first hours after infusions of granulocyte populations of mixed m...

BACKGROUND Dendritic cells (DC) induce tumor or pathogen-specific T cell responses in humans. Several laboratories have developed culture systems, including maturation factors for human DC from peripheral blood monocytes. We comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (MCM), with heparin for their ability to promote uniformly mature DC that e...

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. Cigarette smoke has been considered a major player in the pathogenesis of COPD. The inflamed airways of COPD patients contain several inflammatory cells including neutrophils, macrophages,T lymphocytes, and dendritic cells (DCs). The relative contributions of these various inflammatory cells to airway ...

Sequential or simultaneous leukocyte kinetic studies using radioactive diisopropylfluorophosphate and radiochromate (31Cr) yielded similar or identical blood leukocyte disappearance curves in seven patients with chronic myelocytic leukemia (CML). Body surface counting regularly showed a rise in the spleen counting rate during the first hours after infusions of granulocyte populations of mixed m...

The present investigation examined the effect of interleukin-1beta (IL-1beta) on progesterone production by human luteal cells and the expression and localization of the IL-1 system in the human corpus luteum (CL). Luteal cells were isolated from corpora lutea collected throughout the luteal phase. After dispersion, luteal cells were treated with a panel of monoclonal antibodies directed to leu...