نتایج جستجو برای: mitotic index
تعداد نتایج: 432190 فیلتر نتایج به سال:
Cutaneous mast cell tumor (MCT) shows a variable biological behavior in dogs and may present either as solitary masse that can be treated and cured with surgical removal or as a systemic metastatic and fatal disease. Histological grade, KIT pattern and proliferative index are typically prognostic factors in MCTs. In the present study, we have investigated correlation between clinical data (bree...
The genotoxic potential of the commercial herbicide Illoxan (containing 284 g/L diclofop-methyl) was determined by using chromosome aberrations in Allium cepa root tip cells. The EC50 value was determined as 150.00 mg/L using a root growth inhibition test and then the roots were treated with 37.50, 75.00, and 150.00 mg/L concentrations for 12, 24, and 48 h. The results indicated that Illoxan si...
The influence of a permitted yellow food colour, Sunset yellow –FCF on root tips of Allium sativum was investigated with a view to ascertaining its mitodepressive effect. Root tips of Allium sativum were treated with five concentrations of Sunset yellow like 100 ppm,250 ppm,500 ppm,750 ppm and 1000 ppm and with distilled water as control. The time of action of the respective concentration of so...
In observations on three strains of green hydra, the host and the algal mitotic index is closely coordinated only for the smallest. As the hydra strain size increases the coordination of host and algal mitosis progressively breaks down, first in timing for a medium-sized strain and then in rate for a large strain. Despite disparities between host and algal mitotic index, the number of algae per...
To examine how long after their collection samples of peripheral blood could be successfully cultured for cytogenetic analysis in tropical countries, we determined the mitotic index in cultures of blood stored for up to 7 days in summer and winter. The results indicate that chromosomal analysis is successful if blood is stored for up to 2 days in summer or for up to 4 days in winter before init...
The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 consecutive days in escalating dose cohorts, with skin and tumor biopsies obtai...
Italico rats were injected with thymidine-(3)H 6 hr after the end of 300 hr of intermittent cold treatment. This plan of experiment ensured replacement in the adrenal medulla of lost DNA which is specifically sensitive to cold treatment and has a labeling index sufficiently high for statistical evaluation. The labeling index in the adrenal medulla decreases to one-half of the initial value with...
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro.
Ciprofloxacin is a bactericidal drug which is being used widely throughout the world for the treatment of various bacterial infection. Cytotoxicity and genotoxicity of Ciprofloxacin on human lymphocytes in vitro had been assessed taking various parameters like mitotic index (MI), chromosome aberration (CA), anaphase anomalies, replicative index (RI) and sister chromatid exchange (SCE) as end po...
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