Lemasters, John J. Mechanisms of Hepatic Toxicity. V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1–G6, 1999.—Opening of a high-conductance pore conducting solutes of molecular mass ,1,500 Da causes onset of the mitochondrial permeability transition (MPT). Cyclosporin A blocks thi...