ABSTRACT Physiologists often assume that mitochondria are the main producers of reactive oxygen species (ROS) in cells. Consequently, biomedicine, considered as important targets for therapeutic treatments, and evolutionary biology, they mediators life-history tradeoffs. Surprisingly, data supporting such an assumption lacking, at least partially due to technical difficulties accurately measuri...

We provide evidence that ablation or inhibition of, uncoupling protein 1 increases the rate of reactive oxygen containing species production by mitochondria from brown adipose tissue, no matter what electron transport chain substrate is used (succinate, glycerol-3-phosphate or pyruvate/malate). Consistent with these data are our observations that (a) the mitochondrial membrane potential is maxi...

brucellosis is an infectious disease with high impact on innate immune responses which is induced partly by its dna. in the present study the potential differences of wild type and patients isolates versus attenuated vaccine strains in terms of cytokines, ros and no induction on murine splenocytes and peritoneal macrophages were investigated. this panel varied in base composition and included d...

plants face many biotic and abiotic stresses at the same time during their growth under field conditions. plants responses toward combined stresses are often more complex than their responses to one type of stress in a way that the results of these responses are called as cross tolerance. this mixture of stresses activates specific models of gene expression that causes special signaling network...