Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed Microprocessor that composed of RNase enzyme Drosha and DGCR8, the second another Dicer. There many examples miRNAs poor substrates for Dicer, owing to their suboptimal structures. However, a number these known be expressed at same or higher level as neighboring structurally-optimal m...

cardiovascular disease has become the main factor of death and birth defects in the world. there are some therapeutic structures and drugs for curative and palliative therapy of the disease, but to the aim of accessing reliable therapy or to postpone onset of disease, especially for individuals with heritable coronary artery disease in their pedigree genetic engineering technologies are making ...

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, complex regulatory network, more than 60% human genes. MiRNAs key regulators immune response affect maturation, proli...

Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis sarcoma limited, and designing effective treatments difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, roles miRNAs exosomes remain unclear. The present analysis tissue serum miRNA expression osteosarcoma, Ewing's dediffer...

MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent Studies opened the way for the use of circulating miRNAs as non-invasive diagn...