This paper presents empirical evidence on the e¢ cacy of forecast averaging using the ALFRED real-time database. We consider averages taken over a variety of di¤erent bivariate VAR models that are distinguished from one another based upon at least one of the following: which variables are used as predictors, the number of lags, using all available data or data after the Great Moderation, the ob...

Extra-cellular ligands and cytokines instruct stem cells to pick specific fates and to activate corresponding genetic programs into differentiation. When a stem cell responds to such an external cue, it is first specified to take a particular differentiation route and then becomes irreversibly obliged or committed, to its future fate. Only later, upon full activation of the new genetic program ...

Objective: To investigate the status miR-155 and its targeting eNOS under the stimulation of glucose and ageBSA and to explore the effect of icariside II (ICA II) on the diabetic endothelial dysfunction of human cavernous endothelial cells (HCECs) by using the miR-155 pathway. Methods: Purified HCECs were divided into three groups: normal group + BSA (NC group), Glucose + Age-BSA group (DM grou...

Liposarcoma (LPS) is the most common soft tissue sarcoma. It has been demonstrated that mir-155 was the most overexpressed miRNA in well-differentiated LPS(WDLPS)/dedifferentiated LPS (DDLPS). The aim of this study is to evaluate the involvement of Dicer, Drosha and mir-155 in development of LPS and their possible role in stratification of different histological subtypes. Dicer, Drosha and mir-...

MicroRNAs (miRNAs), a group of small non-coding RNAs, can regulate gene expression by triggering translation repressing and/or RNA degradation. Recent studies proved that they were deeply involved in tumorigenesis. Here we show that, compared with the two normal prostate cell lines, eighteen miRNAs in the array were over-expressed and 18 showed lower levels of expression in at least 2 of 3 canc...

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) context may provide an efficient and safe therapeutic knockdown effect and can be driven by ribonucleic acid polymerase II (RNAP II). In this study, we designed and synthesized miR155-based artificial miRNAs against heparanase (HPSE) constructed with BLOCK-iT™ Pol II miR RNAi Expression Vector Kit. The expression levels of HPSE decl...

Objective: To investigate the status miR-155 and its targeting eNOS under the stimulation of glucose and ageBSA and to explore the effect of icariside II (ICA II) on the diabetic endothelial dysfunction of human cavernous endothelial cells (HCECs) by using the miR-155 pathway. Methods: Purified HCECs were divided into three groups: normal group + BSA (NC group), Glucose + Age-BSA group (DM grou...

Objective: To study the relationships of microRNA-155 (miR-155) expression with the clinicopathological features and prognosis in patients with abdominal aortic aneurysm (AAA). Methods: One hundred and sixteen cases with AAA were selected for the case group, and one hundred and thirty elderly individuals who had undergone physical examination during the same period at The First Affiliated Hospi...

Helminthic infections fall under neglected tropical diseases, although they inflict severe morbidity to human and causes major economic burden on health care system in many developing countries. There is increased effort to understand their immunopathology in recent days due to their immuno-modulatory capabilities. Immune response is primarily controlled at the transcriptional level, however, m...

This paper investigates the performance of three types of random coefficients logistic regression models; that is, models using parametric, semi-parametric, and nonparametric specifications of the distribution of the random effects. Whereas earlier studies focussed on models with a single random effect, here we look at models with multidimensional random effects (intercepts and slopes). Moreove...