Demokrat Parti (DP), 1950 genel seçimlerinden sonra iktidara gelmiş ve on yıl boyunca ülkeyi yönetmiştir. Cumhuriyet Halk Partisi (CHP) ile DP arasındaki siyasi mücadele, iktidarı döneminde şiddetli bir şekilde devam etmiştir. İki parti DP’nin iktidardan indirilmesi sona ermiştir. 27 Mayıs 1960 yılında Milli Birlik Komitesi (MBK) tarafından ülkede askeri darbe yapılmıştır. darbesi birlikte ikti...

micrornas (mirnas) are a class of small non coding regulatory rnas that have key functions in multiple cell processes. deregulation of these tiny mirnas are involved in various human diseases. mir-155 is one of the multifunctional mirna that its over-expression has been found to be associated with different kinds of cancer such as leukemia, breast and colon cancers. it is thought that deregulat...

Objective(s): Autophagy-related 4B (ATG4B) plays an important role in the process of autophagy induction. However, the molecular events that govern the expression of ATG4B in this process are not well known. Materials and Methods: Human ATG4B 3'-UTR region (1377 nt) containing miR-34a/miR-34c-5p binding site was amplified by PCR. Luciferase assay was used to assess the activity of reporter gene...

Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evaluated quantitative expression of miR-21 and miR-155 as two oncomiRs and seve...

MicroRNAs have emerged as important regulators of the metastatic process. In addition, circulating miRNAs appear to be surprisingly stable in peripheral blood making them ideal noninvasive biomarkers for disease diagnosis. Here, we performed a proof-of-principle study investigate expression profile and their association with lymph node status early breast cancer patients. Sentinel was detected ...

The Ras homolog (Rho) family of small GTPases comprise several proteins with prominent roles in regulation cell cycle transition, migration, and remodeling actin cytoskeleton. Expression these is regulated by factors among them are long non-coding RNAs (lncRNAs). impact lncRNAs on Rho signaling can be exerted through direct modulation expression or influencing miRNAs that negatively regulate GT...

Objective(s): To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and ...