The aim of this study was to investigate the effect of commonly used botanicals on UDP-glucuronosyltransferase (UGT) 1A4, UGT1A6, and UGT1A9 activities in human liver microsomes. The extracts screened were black cohosh, cranberry, echinacea, garlic, ginkgo, ginseng, milk thistle, saw palmetto, and valerian in addition to the green tea catechin epigallocatechin gallate (EGCG). Formation of trifl...

Understanding spatial and temporal variation in factors influencing plant regeneration is critical to predicting plant population growth. We experimentally evaluated seed limitation, insect herbivory, and their interaction in the regeneration and density of tall thistle (Cirsium altissimum) across a topographic ecosystem productivity gradient in tallgrass prairie over two years. On ridges and i...

Extracts from the seeds of milk thistle, Silybum marianum, are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in vivo. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B, ...

Silymarin is an extract of milk thistle seeds, consisting of four major classes of flavonoligans: silybinin, silychristin, silydianin and isosilyibinin. These compounds are known for their anti-oxidant and anti-inflammatory properties. The goal of this study was to determine if different fractions of the crude extract of silymarin inhibited proinflammatory cytokine secretion from macrophage and...

Silymarin is the active ingredient of milk thistle. Several studies proved that silymarin has antioxidant, anti-inflammatory and anti-cancer properties. Silymarin is widely used for treatment of hepatic and biliary disorders, renal toxicity and is recently used as adjuvant agent for treatment of cancer.

Because cancer is often treated with combination therapy, unexpected pharmacological effects can occur because of drug–drug interactions. Several drugs are able to cause upregulation or downregulation of drug transporters or cytochrome P450 enzymes, particularly CYP3A4. Induction of CYP3A4 may result in decreased plasma levels and therapeutic efficacy of anticancer drugs. Since the pregnane X r...

1. The present study was conducted to examine the effects of organic extracts from milk thistle (Silybum marianum), turmeric (Curcuma longa), reishi mushroom (Ganoderma lucidum), and shiitake mushroom (Lentinus edodes) on innate immunity and tumor cell viability. 2. Innate immunity was measured by lymphocyte proliferation and nitric oxide production by macrophages, and the inhibitory effect on ...

Silybin A (1), silybin B (2), and isosilybin A (3), three of the seven flavonolignans that constitute silymarin, an extract of the fruits of milk thistle (Silybum marianum), were detected for the first time from a fungal endophyte, Aspergillus iizukae, isolated from the surface-sterilized leaves of S. marianum. The flavonolignans were identified using a UPLC-PDA-HRMS-MS/MS method by matching re...

Diabetes mellitus is a metabolic disorder that results in hyperglycemia due to decreased insulin production or inefficient insulin utilization. This disease has been reported in animals, particularly in aged dogs. However, the disorder is much more prevalent in humans. Millions of people across the globe currently have diabetes and incidence rates are predicted to increase dramatically as the p...