Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. The pre-tibial form is characterized by...

OBJECTIVE To evaluate the prevalence of actinic skin lesions in patients with basal cell carcinoma of the head. METHODS A case-control study was carried out. Cases were patients with primary, solid basal cell carcinoma of the head, less than two centimeters in diameter; and as controls, patients with other dermatoses. Constitutional and behavioral variables were analyzed, as well as actinic l...

Porphyrias are an uncommon, heterogeneous group of metabolic diseases caused by inherited or acquired deficiency of specific enzymes in the heme biosynthetic pathway resulting in an excess of porphyrins (red-brown pigments) and their precursors. Accumulation of heme precursors, such as porphyrinogens that are spontaneously oxidized to porphyrins, is responsible for various clinical features. Po...

OBJECTIVES This manuscript describes the development, validation and clinical application of a novel method for the quantification of the antiretroviral drug efavirenz in dried breast milk spots using LC-MS. METHODS Dried breast milk spots were prepared by spotting 30 μL of human breast milk on each circle of Whatman 903 Protein Saver cards. Chromatographic separation was achieved on a revers...

© 2017 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Sir, A 48‐year‐old otherwise healthy man presented with a 3‐year history of a small painful nodule on the right ear. There was aggravation of pain whenever the patient slept in right lateral position. There was no history of trauma. On examination, the free border of the right helix showed a dome‐shaped, firm nodule ...

Background: Newborns can present with a vast variety of skin lesions. Most of these lesions are physiological, transient, or self-limited and require no therapy. Although a few studies have been done, the results of these studies show differences according to racial and environmental factors. Objective: To study the hospital-based incidence of neonatal dermatoses during the early neonatal perio...

A mine is basically a weapon that can't move and can only attack a target by blowing itself up, a rather primitive approach to warfare. Being required neither to move nor to project power at a distance, mines are relatively cheap; a mine may cost thousands of dollars while a missile or torpedo of equivalent destructive power would cost hundreds of thousands. Being cheap and available on the int...

Rashes are extremely common in newborns and can be a significant source of parental concern. Although most rashes are transient and benign, some require additional work-up. Erythema toxicum neonatorum, acne neonatorum, and transient neonatal pustular melanosis are transient vesiculopustular rashes that can be diagnosed clinically based on their distinctive appearances. Infants with unusual pres...

Objectives: Congenital melanocytic nevi (CMN) are the melanocytic nevi present at birth. Clinical and dermoscopic signs and findings of these nevi diverge from those of acquired nevi. While large CMN bear greater malignant transformation risk, macroscopically surface irregularities and very dark pigmentations reveal atypical appearance. Therefore , it is important to be familiar with characteri...

Autoimmunity to type-WI collagen is characterized by autoantibodies predominantly of lgG class to the non-collagenous domain of type-WI collagen present in the anchoring fibrils which bind basement membrane lamina densa to the anchoring plaques in the dermis. This results in a sublami.na densa split with a blister formation. Type WI collagen autoim.munity is heterogenous in its clinical spectru...