Abstract The GEMPix is a small gaseous detector with highly pixelated readout, consisting of drift region, three Gas Electron Multipliers (GEMs) for signal amplification, and four Timepix ASICs 55 ?m pixel pitch total 262,144 pixels (512×512 pixels). A continuous flow gas mixture (here propane-based tissue equivalent gas) supplied externally at rate 5 L/h. By placing sealed 241 Am source outsid...

Cell damage by high LET radiations has been described by a phenomenological model (track theory) for 20 years and more. Molecules of biological significance (dry enzymes and viruses) act as 1 hit detectors. Recent additions to the class of I-hit detectors are E. Coli B, and the creation of both single and double strand breaks in SV-40 virus in EO buffer, where indirect effects predominate. The ...

The spatial distribution of energy deposition events is an essential aspect in the determination radiobiological effects ionizing radiation at cellular level. Microdosimetry provides a theoretical framework for description these events, and has been used several studies to address problems such as characterization Linear Energy Transfer (LET) Relative Biological Effectiveness (RBE) ion beams pr...

Targeted alpha therapy (TAT) is an emerging option for local and systemic cancer treatment. Preclinical research and clinical trials show that alpha-emitting radionuclides can kill targeted cancer cells while sparing normal cells, thus reducing toxicity. (223)RaCl2 (Xofigo(®)) is the first alpha emitting radioisotope to gain registration in the US for palliative therapy of prostate cancer bone ...