نتایج جستجو برای: microcephaly
تعداد نتایج: 3104 فیلتر نتایج به سال:
846 www.thelancet.com Vol 388 August 27, 2016 Zika virus has been spreading rapidly in Brazil and the Americas, with a sharp increase in the number of notifi ed microcephaly cases since September, 2015. Based on the high number of cases, and the association between Zika virus infection and microcephaly, WHO on Feb 1, 2016, declared a Public Health Emergency of International Concern. Recently, a...
Correct orientation of cell division is considered an important factor for the achievement of normal brain size, as mutations in genes that affect this process are among the leading causes of microcephaly. Abnormal spindle orientation is associated with reduction of the neuronal progenitor symmetric divisions, premature cell cycle exit, and reduced neurogenesis. This mechanism has been involved...
ABSTRACT Purpose: to describe feeding characteristics of children with microcephaly, encompassing the route, food consistencies, and utensils used feed them. Methods: a descriptive study approved by Research Ethics Committee, including 34 caregivers diagnosed microcephaly. They answered structured interview on children’s breastfeeding, them, besides sociodemographic overall development data. De...
Three sibs born to consanguineous parents had congenital nephrotic syndrome, microcephaly, and psychomotor retardation. Pathology of the kidneys showed diffuse mesangial sclerosis with deposits of IgG and C3 in the mesangium and glomerular basement membranes. All three children died before the age of 3 years. Of 19 published cases of children with the association of congenital nephrotic syndrom...
The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies. Further, mice heterozygous for either Magoh or Rbm8a exhibit aberrant neurogenesis and microcephaly. Yet despite the requirement of these genes for neurodevelopment, the pathogenic mechanisms linking EJC dysf...
The microcephaly epidemic in Brazil generated intense debate regarding its causality, and one hypothesised cause of this epidemic, now recognised as congenital Zika virus syndrome, was the treatment of drinking water tanks with pyriproxyfen to control Aedes aegypti larvae. We present the results of a geographical analysis of the association between the prevalence of microcephaly confirmed by Fe...
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