2 Fabrication of microarray devices using traditional glass slides is not easily 3 adaptable to integration into microfluidic systems. There is thus a need for the 4 development of polymeric materials showing a high hybridization signal to 5 background ratio enabling sensitive detection of microbial pathogens. We have 6 developed such plastic supports suitable for highly sensitive DNA microarra...

Fabrication of microarray devices using traditional glass slides is not easily adaptable to integration into microfluidic systems. There is thus a need for the development of polymeric materials showing a high hybridization signal-to-background ratio, enabling sensitive detection of microbial pathogens. We have developed such plastic supports suitable for highly sensitive DNA microarray hybridi...

Protein microarrays represent a powerful technology with the potential to serve as tools for the detection of a broad range of analytes in numerous applications such as diagnostics, drug development, food safety, and environmental monitoring. Key features of analytical protein microarrays include high throughput and relatively low costs due to minimal reagent consumption, multiplexing, fast kin...

in this paper, we propose a new gene selection algorithm based on shuffled frog leaping algorithm that is called sfla-fs. the proposed algorithm is used for improving cancer classification accuracy. most of the biological datasets such as cancer datasets have a large number of genes and few samples. however, most of these genes are not usable in some tasks for example in cancer classification. ...

an important aspect of microarray studies includes the prediction of patient survival based on their gene expression profile. to deal with the high dimensionality of this data, use of a dimension reduction procedure along with the survival prediction model is necessary. this study aimed to present a new method based on wavelet transform for survival relevant gene selection.the data included 204...

BACKGROUND Ulcerative colitis (UC) was the most frequently diagnosed inflammatory bowel disease (IBD) and closely linked to colorectal carcinogenesis. By far, the underlying mechanisms associated with the disease are still unclear. With the increasing accumulation of microarray gene expression profiles, it is profitable to gain a systematic perspective based on gene regulatory networks to bette...

‹ Clinical trial groups (lymphoma, sepsis networks) Tight integration (Direct operation on database) File-based exchange (Data ex-/import to/from tools) Transparent integration (Data access using database API) Probe and gene intensities Sample & Experiment annotations Gene annotations Uniform web-based GUI ‹ Existing tools + own developments ¾ArrayAnalyzer server ¾Statistical algorithms(WG3) ¾C...

For an effective integration of microarray-based technologies in clinical settings a number of contributions from biomedical informatics technologies and techniques are needed to facilitate the improvement of the phases of experimental design, image analysis, data management, annotation, and analysis. In this communication we briefly present the state-of-the-art in the application of biomedical...

Integrative analysis of microarray data has been proven as a more reliable approach to deciphering molecular mechanisms underlying biological studies. Traditional integration such as meta-analysis is usually gene-centered. Recently, gene set enrichment analysis (GSEA) has been widely applied to bring gene-level interpretation to pathway-level. GSEA is an algorithm focusing on whether an a prior...

Microarrays make it possible to monitor the expression of thousands of genes in parallel thus generating huge amounts of data. So far, several databases have been developed for managing and analyzing this kind of data but the current state of the art in this field is still early stage. In this paper, we comprehensively analyze the requirements for microarray data management. We consider the var...