Diabetic retinopathy (DR) caused by diabetes occurs as a result of changes in the retinal vessels and causes visual impairment. Microaneurysms (MAs) are early clinical signs DR, whose timely diagnosis can help detecting DR stages its development. It has been observed that MAs more common inner layers compared to outer eyes suffering from DR. Optical coherence tomography (OCT) is noninvasive ima...

We report a case of bilateral ureteral obstruction most likely caused by polyarteritis nodosa. The diagnosis was based upon muscle biopsy which showed typical necrotizing vasculitis in medium size artery in conjunction with microaneurysms in renal angiography. Ureteral obstruction is a rare manifestation of polyarteritis nodosa. This condition is thought to result from vasculitis of periuretera...

Deficiency of adenosine deiminase 2 (DADA2) syndrome is a recently described autosomal recessively inherited autoinflammatory disorder associated with missense mutations in CECR1 gene. Clinical manifestations include early onset stroke, livedoid vascular changes, and a vasculopathy mimicking classical polyarteritis nodosa (cPAN) characterized by microaneurysms and associated inflammatory findin...

Moyamoya is an intriguing and controrersial syndrome. This patient study senes to align the patbophysiology of intracranial hemorrhage in moyamoya with the cerebral rascular disease seen with hypertension, or aging. The historical eridence Unking lipohyalinosis and microaneurysms to cerebral hemorrhage is reviewed, the pathogenesis of this angiopathy Is discussed, and explanations considered fo...

Pathology The earliest detectable lesions of diabetic retinopathy are microaneurysms. These are associated with excessive vascular permeability and result in exudate formation. There is occlusion of the vessels and stimulation of growth factors, which in turn promote the proliferation of new blood vessels and the growth of fibrous tissue. This may contract and lead to haemorrhage. The process o...

Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or 'soft exudates' either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and...

Two young men, were hospitalized due to acute massive blood loss with left abdominal flank pain. In both cases renal angiography showed signs of a haemorrhagic event in the left kidney, perirenal in one and subcapsular in the other. Microaneurysms indicated a diagnosis of polyarteritis nodosa, supported by renal biopsy in one case. Renal haemorrhage is an infrequent presentation of polyarteriti...

Recently, microaneurysm (MA) detection has attracted a lot of attention in the medical image processing community. Since MAs can be seen as the earliest lesions in diabetic retinopathy, their detection plays a critical role in diabetic retinopathy diagnosis. In this paper, we propose a novel MA detection approach named multifeature fusion dictionary learning (MFFDL). The proposed method consist...