Introduction: Oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. It was previously reported that administration of high levels of vitamin C can lead to increased DNA damage through production of hydroxyl radicals from hydrogen peroxide by the Fenton reaction. However, our early experim...

14.00 800x600 introduction: oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. it was previously reported that administration of high levels of vitamin c can lead to increased dna damage through production of hydroxyl radicals from hydrogen peroxide by the fenton reaction. however, our...

Abstract INTRODUCTION Chimeric antigen receptor (CAR) T cells specific for the glioblastoma (GBM)-specific epidermal growth factor variant III (EGFRvIII; CARvIII) have successfully treated tumors homogeneously expressing EGFRvIII when combined with lymphodepletion, however this is not recapitulated clinically. We generated an “armored” CARvIII which constitutively secretes IL-12, a stimulatory ...

Abstract The mechanisms that drive pathology in infection-induced shock are not well understood. tick-borne pathogen Ixodes ovatuserhlichia (IOE) induces severe inflammation, vascular damage, liver injury, and death. Mice lack the receptor for type I IFN, or receptors both II IFNs, improves survival by 50–70 90%, respectively. IOE infection induced a significant increase circulating granulocyte...

objective: leishmaniasis is one of the most important parasitic infectious diseases in the world. since last century, many efforts have been made to control and treat the disease, but appropriate vaccines, pesticides and medicines are not available or even eligible. the purpose of this study was to evaluate the effect of hydro-alcoholic extract of seidlitzia rosmarinus on the lesions of experim...

This study was designed to determine the in vitro anticancer potential of Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer swiss albino mice. The activity assessed using cytotoxicAity, mean survival time, tumor volume and hematological studies. reliable criteria for evaluating any agent is prolongation lifespan animal decrease WBC count b...

Background To assess embryos derived by the transfer of meiosis-II chromosomes (M-II-t) from aged mice oocytes into ooplasms from younger mice to overcome the problem of age-related decline in female fertility. MaterialsAndMethods The developmental capacity karyotype and ultrastructure of reconstructed oocytes derived from meiosis-II chromosome transplantation from aged mice into the ooplasms o...

background: to compare the pathogenicity differences in two susceptible balb/c and resistant c57bl/6 mice infected with leishmania major mrho/ir/75/er as a prevalent strain of zoonotic cutaneous leishmaniasis in iran. methods : mice were assigned into four groups as control and infected balb/c and c57bl/6 mice. experimental leishma­niasis was initiated by (s. c) injection of the 2×10 6 l. major...

background: routine oocytes cryopreservation remained an elusive technique in the wide ranges of available assisted reproductive technologies. the microtubules of oocytes are vulnerable to cryoprotectants and thermal change during cryopreservation. objective: the effects of a vitrification protocol were investigated on the spindle and chromosome configurations of mice oocytes cryopreserved at t...