نتایج جستجو برای: micb
تعداد نتایج: 187 فیلتر نتایج به سال:
Background Type IV drug hypersensitivity reactions with cutaneous manifestations (cADR) are highly variable in clinical appearance and degree of severity, ranging from maculopapular exanthema (MPE) to more severe disorders such as DRESS or SJS/TEN. Recent studies show NKp46+ cells in skin of drug-induced exanthemas, and NK cells expressing granulysin have been found in blister fluids from SJS/T...
Background Adoptive immunotherapy, including transfer of activated NK cells, is currently under active investigation for patients with refractory and relapsed acute myeloid leukemia (AML). However, a highly immunosuppressive microenvironment sustained in part by tumor-derived exosomes, creates a major hurdle for adoptive immunotherapy. We recently reported that exosomes, virussize (30-100nm) me...
Unlike primary T cells in lymph nodes, effector CD8(+) CTL in tissues do not express the costimulatory receptor CD28. We report that NKG2D, the receptor for stress-induced MICA and MICB molecules expressed in the intestine, serves as a potent costimulatory receptor for CTL freshly isolated from the human intestinal epithelium. Expression and function of NKG2D are selectively up-regulated by the...
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