BACKGROUND Cigarette smoking (smoking), hormone therapy (MHT), and folate intake (folate) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. Expression of estrogen receptor β (ESR2) has been associated with colorectal cancer stage and survival. METHODS In this prospective cohort study, we examined smoking, MHT, and folate...

Gliomas are a group of heterogeneous primary central nervous system (CNS) tumors arising from the glial cells. Malignant gliomas account for a majority of malignant primary CNS tumors and are associated with high morbidity and mortality. Glioblastoma is the most frequent and malignant glioma, and despite the recent advances in diagnosis and new treatment options, its prognosis remains dismal. N...

The melanophores of larval Xenopus laevis are disparately distributed on the hypomere in that the upper region (UHT) is densely pigmented, the median region (MHT) is moderately pigmented, and the lower region (LHT) is unpigmented. The roles of the melanoblasts and their tissue environment in determining the melanophore pattern was investigated by heterotopic transplantation of hypomeric tissues...

[1] We document geodetic strain across the Nepal Himalaya using GPS times series from 30 stations in Nepal and southern Tibet, in addition to previously published campaign GPS points and leveling data and determine the pattern of interseismic coupling on the Main Himalayan Thrust fault (MHT). The noise on the daily GPS positions is modeled as a combination of white and colored noise, in order t...

The Multiple Hypothesis Tracking (MHT) algorithm is known to produce good results in difficult multi-target tracking situations. However, its implementation is not trivial, and is associated with a significant programming effort, code size and long implementation time. We propose a library which addresses these problems by providing a domain independent implementation of the most complex MHT op...

It is now 75 years since Fuller Albright published his observations on the causal relationship between menopausal estrogen deficiency and osteoporosis. He introduced the concept of menopausal hormone therapy (MHT) for the prevention of osteoporosis. Most of his remarkable observations have stood the test of time and scientific scrutiny. Unfortunately, the uptake of MHT for the prevention of ost...

OBJECTIVE This study investigated the relationships between specific performance components, eye-hand coordination, visuomotor integration, in-hand manipulation, and handwriting skill. METHOD A sample of 48 typical first grade students were identified as good and poor handwriters by their teachers. Each child completed the Motor Accuracy Test; the Developmental Test of Visual-Motor Integratio...

The 1714 Bhutan earthquake was one of the largest in Himalaya last millennium. We show that surface rupture caused by this extended further to east than previously known, it at least 175 km long, with slip exceeding 11 m our study site. age constrained a combination radiocarbon and traditional optically stimulated luminescence dating affected river sediments. Computations using empirical scalin...

This paper describes a probabilistic mode-based multihypothesis tracking (MHT) algorithm. The modes are the local maximums refined from initial samples in a parametric state space. Because the modes are highly representative, this technique allows us to use a small number of hypotheses to effectively model non-linear probabilistic distributions. To ensure real-time tracking performance, we prop...