The aim of this study was to investigate the effectiveness of a high-dose zinc sulfate and low-dose D-penicillamine combination in the treatment of pediatric Wilson's disease (WD). A retropective chart review of 65 patients with WD was conducted. These patients received D-penicillamine (8-10 mg/kg/day) and zinc sulfate as the primary treatment. The pediatric dose of elemental zinc is 68-85 mg/d...

A two-stage passive treatment approach was assessed at a bench-scale level using two Colorado Mining Influenced Waters (MIWs). The first-stage was a limestone drain with the purpose of removing iron and aluminum and mitigating the potential effects of mineral acidity. The second stage was a sulfate reducing bioreactor composed solely of 50% corn stover and 50% walnut shells by volume. The prima...

DESCRIPTION levatol® (penbutolol sulfate) is a synthetic ß-receptor antagonist for oral administration. The chemical name of penbutolol sulfate is (S)-1-tert-butylamino-3-(o-cyclopentylphenoxy)-2­ propanol sulfate. It is provided as the levorotatory isomer. The empirical formula for penbutolol sulfate is C36H60N2O8S. Its molecular weight is 680.94. A dose of 20 mg is equivalent to 29.4 μmol. Th...

PURPOSE In part A, the aim was to define the maximum tolerated dose (MTD) of the hydrogen sulfate (Hyd-Sulfate) oral capsule formulation of the mitogen-activated protein kinase kinase inhibitor AZD6244 (ARRY-142886). In part B, the aim was to compare the pharmacokinetic profile of the new Hyd-Sulfate capsule with the initial AZD6244 free-base suspension and further characterize the pharmacodyna...

Sulfate-rich acid waters produced by oxidation of sulfide minerals enhance U mobility around U ores and U-bearing radioactive waste. Upon evaporation, several secondary uranyl minerals, including many uranyl sulfates, precipitate from these waters. The zippeite-group of minerals is one of the most common and diverse in such settings. To decipher the nature and crystal chemistry of the zippeite-...

Even though aluminum is the third most common element present in the earth's crust, information regarding its toxicity remains scarce. It is known that in certain cases, aluminum is neurotoxic, but its effect in other tissues is unknown. The aim of this work was to analyze the genotoxic potential of aluminum sulfate in kidney tissue of the fish Rhamdia quelen after trophic contamination for 60 ...

Fractionation of rat mammary gland extracts by ion eschange chromatography has led to the isolation of a new low molecular weight derivative of neuraminic acid. This compound appears to be a sulfuric ester of neuramin-lactose (1) and, therefore, the name neuramin-lactose sulfate is here proposed for it. Glands obtained from the first to the sixth da.y after delivery contained an average of 3.4 ...

The Curiosity rover in Gale crater is investigating a mineral transition observed from orbit – an older “clay unit” to younger “sulfate hypothesized reflect the aridification of Mars’ climate. Below this transition, detected crystalline Ca-sulfates with minor Fe-sulfates but also found that some fraction rock’s bulk SO3 often poorly constrained X-ray amorphous component. Here, we characterize a...

background copper (cu) is an essential trace element involved in normal reproduction but its overexposure may produce some detrimental effects. the aim of this study was to investigate the effects of copper sulfate poisoning on morphometery of mice ovarian structures and probable intracellular changes. methods thirty mature female mice were randomly allocated to control and two treatment groups...