The Center for Disease Control guidelines recommend desensitization to metronidazole in patients with trichomoniasis and hypersensitivity to metronidazole. There is only one published oral metronidazole desensitization protocol. The purpose of this study was to design a new, more gradual oral desensitization protocol to decrease systemic reactions that may occur when using the previously publis...

The objective of the present multicenter observational study was to assess postoperative infections as a function of risk factors and antibiotic prophylaxis under everyday clinical conditions. 2513 patients from 114 centers in Germany who received infection prophylaxis prior to elective colonic resection were included in the study between 1st September 1996 and 30th September 1997. In the descr...

The rate of bactericidal activity and inactivation of metronidazole was studied in time-kill curves with Haemophilus vaginalis (Corynebacterium vaginale). The minimum inhibitory concentrations of metronidazole for the eight strains tested ranged from 4 to 16 micrograms/ml. At a concentration of 20 micrograms/ml, metronidazole demonstrated a slow cidal effect against exponential-phase organisms,...

OBJECTIVE Due to the high incidence of bacterial vaginosis (BV) and its resistance to chemical medications and considering the anti-bacterial and anti-fungal effects of Myrtus communis, the present study aimed to compare the therapeutic effects of the vaginal gel of M. communis 2% (in metronidazole base) with metronidazole vaginal gel 0.75% alone on BV. MATERIALS AND METHODS This research was...

OBJECTIVE We sought to compare the efficacy of metronidazole gel vs. triple-sulfa cream in the treatment of bacterial vaginosis (BV). METHODS In a double-blinded study, 247 women with symptomatic BV were randomly assigned to receive either 5 g of 0.75% metronidazole gel twice daily for 5 days or triple-sulfa cream twice daily for 5 days. There were 205 (96 treated with metronidazole and 109 t...

It has been suggested that the microbicidal effect of metronidazole is mediated by an intermediate in nitro group reduction. We have found that the addition of Escherichia coli enhances the lethal effect of metronidazole on Bacillus fragilis and suggest that this intermediate may form in one bacteria and kill another. Because acetamide forms during the reduction of metronidazole, we examined th...

background: metronidazole, a 5-nitroimidazole derivative, is the main antitrich­omonal agent of  choice   for   treatment  of t richomoniasis . since 1962, s ome cases of treatment failure with metronidazole have been reported and recently drug re­sistance is now on the rise in the world. this study was aimed to determine current susceptibility of iranian isolates of trichomonas vaginalis to me...

background: giardia lamblia is a common intestinal parasite associated with social or personal problems. giardiasis is distributed all over the world; however, the infection is more prevalent in developing countries. metronidazole is now considered as a drug of choice for giardiasis treatment. the increasing number of reports of refractory cases as well as side effects of this drug resulted in ...