Evidence-Based Answer No recent evidence demonstrates that methylphenidate improves fatigue in patients receiving palliative care. Methylphenidate can be used to minimally improve fatigue symptom scores in patients with cancer-related fatigue. (Strength of Recommendation [SOR]: C, based on a meta-analysis of multiple randomized controlled trials [RCTs] with heterogeneous results.) Methylphenida...

OBJECTIVE Previous studies comparing atomoxetine and methylphenidate to treat ADHD symptoms have been equivocal. This noninferiority meta-analysis compared core ADHD symptom response between atomoxetine and methylphenidate in children and adolescents. METHOD Selection criteria included randomized, controlled design; duration 6 weeks; and assessment of ADHD Rating Scale-IV-Parent Version: Inve...

Background: Methylphenidate is one of the most common medications used for treatment of attention-deficit/hyperactivity disorder. It may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. The occurrence of alteration in male reproductive system such as hormonal secretion changes and alteration of testicular sperm...

Background: Methylphenidate commonly known as Ritalin is one of the most common medications. The administration of Ritalin leads to increase of the activity of central nervous system. Because of this property, Ritalin may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. There is a little data about the effects ...

Background: Drug treatment is one of the most important treatments for attention deficit hyperactivity disorder (ADHD). The DRD4 gene a transporter and receptor coding dopamine genes under investigation in etiology ADHD. In this study, association between rs3758653 C/T VNTR exon 3 repetition polymorphisms effects methylphenidate were investigated patients with ADHD consuming methylphenidate. Me...

Psychostimulants, such as methylphenidate, are thought to improve information processing in motivation-reward and attention-activation networks by enhancing the effects of more relevant signals and suppressing those of less relevant ones; however the nature of such reciprocal influences remains poorly understood. To explore this question, we tested the effect of methylphenidate on performance a...

INTRODUCTION Methylphenidate is a psychostimulant that has been used to relieve depressive symptoms in advanced cancer patients. No studies compare its efficacy against placebo in this group of patients. OBJECTIVE To explore the efficacy of methylphenidate compared with placebo in the relief of depressive symptoms in advanced cancer patients. MATERIAL AND METHODS A multicentre, double-blind...

Abstract Background Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychological disorders that affects children, adolescents, and adults. Dysfunction hypothalamic-pituitary-adrenal axis (HPA) has been implicated in its pathophysiology. So, this study aimed to compare salivary cortisol level between ADHD children healthy children. It also compared before treatmen...

The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear how they work or why they improve performance in some individuals but impair it in others. To test the hypothesis that stimulants enhance signal to noise ratio of neuronal activity and thereby reduce cerebral activity by increasing efficien...