Experiments were carried out to study the effect of acetoacetate admini stration on pyridine nucleotides in liver and blood in male albino rats. Acetoacetate, when administered along with tryptophan (through diet) to tryptophan-niacin-deficient rats for twenty days, resulted in decreased pyridine nucleotide values as compared to the corresponding controls. Prolonged administration of acetoaceta...

Bentourkia M, Tremblay S, Pifferi F, Rousseau J, Lecomte R, Cunnane S. PET study of C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis. Am J Physiol Endocrinol Metab 296: E796 –E801, 2009. First published January 27, 2009; doi:10.1152/ajpendo.90644.2008.—Normally, the brain’s fuel is glucose, but during fasting it increasingly relies on ketones ( -hydroxybutyrate, ...

Previous studies have shown that the metabolism of acetone and acetate by the photosynthetic bacterium, Rhodopseudomonas gelatinosa, requires either light or oxygen as a source of energy (1, 2). The studies also showed that the cleavage of acetoacetate to acetat.e did not require an external source of energy. These observations are consistent with the known thermodynamic properties of the react...

The secondary signals emanating from increased glucose metabolism, which lead to specific increases in proinsulin biosynthesis translation, remain elusive. It is known that signals for glucose-stimulated insulin secretion and proinsulin biosynthesis diverge downstream of glycolysis. Consequently, the mitochondrial products ATP, Krebs cycle intermediates, glutamate, and acetoacetate were investi...

Previous studies have shown that the metabolism of acetone and acetate by the photosynthetic bacterium, Rhodopseudomonas gelatinosa, requires either light or oxygen as a source of energy (1, 2). The studies also showed that the cleavage of acetoacetate to acetat.e did not require an external source of energy. These observations are consistent with the known thermodynamic properties of the react...

1. Acetoacetate or dl-beta-hydroxybutyrate increases the rate of oxygen consumption to a smaller extent than that brought about by glucose or pyruvate in adult rat brain-cortex slices but to the same extent as that in infant rat brain-cortex slices. 2. The rate of (14)CO(2) evolution from [1-(14)C]glucose considerably exceeds that from [6-(14)C]glucose in respiring infant rat brain-cortex slice...

Biginelli reaction of ethyl acetoacetate, thiourea and the appropriate aromatic aldehyde was used to produce ethyl 4-aryl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates, that reacted with bromomalononitrile to give ethyl 3-amino-5-aryl-2-cyano-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylates rather than the isomeric 7H-thiazolo[3,2-a]pyrimidines. Thiazolopyrimidine derivative...

It has been established that rat liver slices are able to convert acetate (l), acetone (2), pyruvate (3, 4), butyrate, hexanoate, and octanoate (4) to cholesterol and long chain fatty acids. Zabin and Bloch (5) and Price and Rittenberg (6) administered 1 ,3-C14-acetone to rats and demonstrated that it is converted to fatty acids and cholesterol. The former investigators (5) also reported that m...