Literature data on epidemiology, mechanisms of development, features the course cognitive disorders in type 2 diabetes mellitus (T2DM), as well prospects for their treatment and prevention were analyzed. Diabetes is recognized an independent factor impairment associated with increased risk dementia, main causes which are Alzheimer’s disease vascular dementia. Results recent research have shown ...

Hyperinsulinemia and insulin secretion abnormalities Hyperinsulinemia causing IR. Jesse Roth (New York, NY) suggested that, rather than IR, hyperinsulinemia should be considered the major mediator of adverse outcome, with hyperinsulinemia the underlying characteristic of all syndromes of IR (1). Recalling Edgar Allan Poe’s story “The Purloined Letter,” Roth argued that the mediator of IR is ins...

results there was no statistical difference between the 2 groups with respect to the recurrence rate (p > 0.05). although the recurrence interval was longer for the metformin group, this increase was not statistical significant (p > 0.05). furthermore, tumor recurrence had no correlation with sex or the grade of the tumors. conclusions according to our findings, it seems that metformin has no c...

Polycystic ovary syndrome is a heterogeneous endocrine disease that affects women of childbearing age. The pathogenesis polycystic has not been fully studied to date, its paradigm considers the genetic determinism manifestation hormonal and metabolic disorders, which are considered be criteria for verification (hyperandrogenism, oligo/anovulation and/or ovarian transformation during ultrasound ...

background: metformin is used to lower blood sugar in patients with type ii diabetes. recent research showed that metformin has effects on cancer cell growth. studies show that metformin can induce apoptosis in certain cancer cell lines. in this study, we examined the effect of metformin on apoptosis in the t47d breast cancer cell line. methods : the t47d breast cancer cell line was selected an...

Membrane Fluidity in Hypertensive Subjects To the Editor: We read with great interest the recent article by Dr Rheaume and colleagues1 dealing with a possible link between insulin sensitivity and carbohydrate metabolism in hypertensive subjects. The results of their study demonstrated that insulin sensitivity at rest was lower and not improved by exercise in hypertensive subjects. In addition, ...

BACKGROUND Insulin resistance and increased ovarian cytochrome P450c17 alpha activity are both features of the polycystic ovary syndrome. P450c17 alpha, which is involved in androgen biosynthesis, has both 17 alpha-hydroxylase and 17,20-lyase activities. Increased activity of this enzyme results in exaggerated conversion of progesterone to 17 alpha-hydroxyprogesterone in response to stimulation...

Abstract Pancreatic ductal adenocarcinoma (PDCA) is a leading cause of cancer death in the US. Patients diagnosed with PDCA generally present advanced disease poor prognosis and limited treatment options. African American patients have higher incidence mortality than Caucasian or any other ethnic group. Different factors been attributed to contribute this health disparity, among them Diabetes M...

especially in the presence of atypia, has a strong tendency to the development of endo-metrial carcinoma. In this respect, hysterectomy is a preferred treatment for atypical EH. However, for young patient who desire to preserve their fertility or for patients not selected for surgery, conservative treatments using progestin are widely accepted as a treatment option [1]. Oral use of progestin, s...

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Vaspin levels increase with hyperinsulinemia and obesity. Currently, no data exists on vaspin in PCOS women. Objectives: To assess mRNA and protein levels of vaspin from subcutaneous (sc) and omental (om) adipose tissue (AT) of PCOS women and matched controls, including circulating vaspin. Ex vivo regulation of ...