Among the renal lesions described, cell carcinoma (RCC) is primary neoplastic tumor reaching males in a proportion two times higher than females and characterizing about 2% of carcinomas adult population. Although treatment this type cancer has evolved recent years, management patients with metastatic conditions remains challenging, possible spreads to lungs bones. Vascular metastasis RCC skin,...

High-mobility group AT-hook 2 (HMGA2), a member of the high mobility group family, has been reported to correlate with cancer progression. However, there is no report concerning the correlation between HMGA2 and metastasis in renal cell carcinoma. In the present study, we found that HMGA2 was highly expressed in five renal cell carcinoma cell lines compared with that in the normal renal tubular...

Tumor-to-tumor metastasis is a rare phenomenon. From our review of the international literature, around 150 cases have been reported since it was first documented by Campbel in 1868. Renal clear cell carcinoma is well known to be the most common recipient of tumor-to-tumor metastasis in all tumors. However, renal chromophobe cell carcinoma has not been reported to be a recipient. Here, we repor...

An elderly man presented with iron deficiency anemia and intermittent rectal bleeding. His past medical history was significant for a renal cell carcinoma resected 9 years earlier. After a colonoscopy and upper endoscopy were unremarkable, he underwent a small bowel capsule endoscopy, which revealed an ulcerated mass in the jejunum (Figure 1 and Video 1). Surgical resection was performed, and t...

A 54-year-old female had a 9-cm left renal mass with a 12-cm aorto-caval mass lesion mimicking an enlarged lymph node. Retroperitoneal dissection and left radical nephrectomy were performed, and pathology revealed a left renal mucinous tubular and spindle cell carcinoma combined with a retroperitoneal ganglioneuroma. The patient has had no local recurrence or distant metastasis after 3 years' f...

BACKGROUND Renal cell carcinoma most commonly metastasizes to the lungs, skeleton or liver. Metastatic renal cell carcinoma to the breast is very rare, especially for clear cell carcinoma, and few cases regarding this condition have been reported. CASE PRESENTATION The case we presented was a 68-year-old Chinese female with metastatic renal clear cell carcinoma of the left breast 10 years aft...

According to GLOBOCAN, there were about 18 million new cases of cancer and 9.6 deaths from malignancies worldwide in 2018. Renal cell carcinoma is a malignant tumor characterized by the loss VHL gene, which leads increased angiogenesis. The potential immuno-oncology anti-angiogenic drugs has significantly improved outcomes for patients with metastatic renal carcinoma. phase III CheckMate 9ER st...

Despite great improvements in the management of metastatic clear cell renal carcinoma, complete responses with antiangiogenic therapies are infrequent and complete pathological responses remain anecdotal. We report the complete pathological response of a solitary bone metastasis from a clear cell renal carcinoma after sequential treatment with sunitinib and radiotherapy. In February 2009, a fem...