Abstract Aim The aim of this study was to clarify the significance resection ovarian metastases from colorectal cancer and identify clinicopathologic characteristics. Methods In multicenter retrospective study, we evaluated data on obtained patients at 20 centers in Japan between 2000 2014. We examined impact prognosis with prognostic factors. Results included 296 metastasis. 3‐y overall surviv...

Objective: Lung cancer is the most common worldwide and among leading causes of death. The aim this study to examine survival patients who received radiotherapy for brain metastases, whose primary non-small cell lung cancer, also determine factors that are like affect results in these as well. Materials Methods: This included 99 with cancer. All metastases radiotherapy. were grouped compared ac...

BACKGROUND Women with triple-negative (TN) breast cancer are at increased risk of distant metastases and have reduced survival versus other breast cancer patients. Relative survival of women with TN breast cancer who develop brain metastases is unknown. METHODS Patients with breast cancer who developed brain metastases at our institution from 1993 to 2006 were reviewed. Four survival time int...

BACKGROUND AND OBJECTIVES The Japanese protocol considers metastases to retroperitoneal or lateral pelvic lymph nodes (RLPNs) as regional lymphatic dissemination in rectal adenocarcinoma patients and recommends total mesorectal excision (TME) plus retroperitoneal and lateral pelvic lymphadenectomy (RLPL). Western protocols consider RLPN metastases to indicate advanced disease. METHODS All out...

BACKGROUND Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clin...

Background There are few population-based studies of the sites of distant metastasis (DM) and survival from esophageal cancer (EC). The aim of this study was to assess the patterns and survival outcomes for site-specific DM from EC using a population-based approach. Methods Patients diagnosed with de novo stage IV EC between 2010 and 2014 were identified from the Surveillance, Epidemiology, a...

This study was performed to investigate the expression of reactive oxygen species (ROS)-related proteins and to analyze the implications for primary and metastatic breast cancer. We constructed a tissue microarray containing 143 metastatic breast cancers (52 lung metastases, 38 bone metastases, 37 brain metastases, and 16 liver metastases) and performed immunohistochemical staining for ROS-rela...

diagnosis, degree of surgical resection or prior treatment and subsequent development of extraneural metastases was found [4]. The exact route of extraneural metastases is not known, but in the vast majority metastases occurred in the wake of craniotomy, suggesting iatrogenic vascular seeding [3]. Typically, extraneural metastases of ependymoma occur in the lungs, pleura, and lymph nodes while ...

BACKGROUND Due to local ventilation and perfusion differences in the pulmonary lobes, the microenvironmental influence on metastasis formation in the lung can be studied. We, therefore, investigated whether the anatomical distribution of first lung metastases follow a particular pattern. MATERIALS AND METHODS Thirty-three out of 273 patients with melanoma who underwent 18F-fluorodeoxyglucose ...

BACKGROUND 40-50% of patients with colorectal cancer (CRC) will develop liver metastases (CRLM) during the course of the disease. One third of these patients will additionally develop pulmonary metastases. METHODS 137 consecutive patients with CRLM, were analyzed regarding survival data, clinical, histological data and treatment. Results were stratified according to the occurrence of pulmonar...