Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad range of peptide derivatives straightforwa...

ment, whose objective is to empower domain experts themselves to specialize AM-PHION to an application domain. It is meant to be the automatic programming analogue of application generator generator technology. META-AMPHION will include an extension of the current user interface to guide domain experts in creating and extending a domain theory (in fact, the current user interface is already sui...

OBJECTIVE to identify values which structure and guide nursing as social practice. METHOD qualitative meta-synthesis. RESULTS three concepts were identified: The tension between technique, organization and ethics in the nurse's practice; Historical carry-overs of the values which run through nursing practice; Attention to ethics, to reform of the health system, and to the humanization of ca...

Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase. Here we adapted this technology to establish a novel modular antibody labeling approach which is...

This paper explores how meta-studies can support the development of process-based land change models (LCMs) that can be applied across locations and scales. We describe a multi-step framework for model development and provide descriptions and examples of how meta-studies can be used in each step. We conclude that meta-studies best support the conceptualization and experimentation phases of the ...