Dopamine containing neurons arise mainly from DA cell bodies in the substantia nigra and ventral tegmental area in mid-brain region (Tarazi, et aI., 2001; 1996; Creese, et. aI., 1997; Royh, et. aI., 1991; Carlsson, 1993; Lookingland, et aI., 1995). Dopaminergic system is organized into four major subsystems (i) the nigrostriatal system involving neurons projecting from the substantia nigra pars...

BACKGROUND Several findings in humans support the hypothesis of links between n-3 polyunsaturated fatty acid (PUFA) status and psychiatric diseases. OBJECTIVE The involvement of PUFAs in central nervous system function can be assessed with the use of dietary manipulation in animal models. We studied the effects of chronic dietary n-3 PUFA deficiency on mesocorticolimbic dopamine neurotransmis...

Our on going studies have sought to simulate circuit properties of the mesocortical dopaminergic system. This article describes a reduced model which elucidates the essential nature of dopaminergic modulation in the prefrontal cortex (PFC). Simulating a delayedresponse task, we observed that the delay-period activity of the model neurons follows an inverted-U-shaped curve according to the incre...

background: sustainable and commercial production of taxol as an anti cancer drug is a critical point to its clinical application. nowadays, hazel because of rapid growth and wide range distribution is considered as an alternative source of taxol. objective: to increase taxol production the cdna encoding 3-hydroxy-3-methylglutaryl-coa reductase (hmgr) from iranian hazel (genebank accession numb...

objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...