background: the use of stem cells is considered as an appropriate source in cell therapy and tissue engineering. differentiation of human induced pluripotent stem cells (hipscs) to hepatocyte-like cells (hlcs) on mouse embryonic fibroblasts (mefs) feeders is confronted with several problems that hinder the clinical applications of these differentiated cells for the treatment of liver injuries. ...

Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...

background: recent publications about differentiation of stem cells to germ cells have motivated researchers to make new approaches to infertility. in vitro production of germ cells improves understanding differentiation process of male and female germ cells. due to the problem of using embryonic stem cells (esc), it’s necessary the mentioned cells be replaced with some adult multi-potent stem ...

Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases. Inflammatory mediators proteolytic enzymes released by activated cells induce serious injury corneal epithelial retinal ganglion cell which may result vision loss. Mesenchymal stem (MSCs) are regulatory produce various immunosuppressive factors that modulate phenotype func...

objective(s):the application of stem cells holds great promises in cell transplants. considering the lack of optimal in vitro model for hepatogenic differentiation, this study was designed to examine the effects of laminin matrix on the improvement of in vitro differentiation of human bone marrow mesenchymal stem cells (hbm-msc) into the more functional hepatocyte-like cells. materials and meth...

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objective(s) it is believed that the mesenchymal stem cell (msc) differentiation and proliferation are the results of activation of wnt signaling pathway. on the other hand, lithium chloride is reported to be able to activate this pathway. the objective of this study was to investigate the effect of lithium on in vitro proliferation and bone differentiation of marrow-derived msc. materials and ...

today’s tissue engineering is an important and interested method to treatment of  bone lesions so tissue engineering specialists and orthopedic surgeons are forced to serve as a safe alternative to current methods.the introduction ofa scaffoldthathas thebestefficiencyisamajor challengeto scientistsand researchersin this field.the aim ofthisstudy is to investigatethe polyaniline(pani) influence ...

Mesenchymal Stem Cells (MSC) are classically categorised as spindle shaped fibroblastic-like cells that form colonies in vitro cultures. As stem cells, they are self-renewable and have potential to differentiate into the mature mesodermal lineages such as osteocytes, adipocytes and chondrocytes. Although, MSC are non-haematopoietic, yet they support haematopoiesis in adult bone marrow (BM) and ...

BACKGROUND Mesenchymal stem cells (MSC) play important roles in modulating the activities of T lymphocytes, dendritic cells and natural killer cells. These immunoregulatory properties of MSC suggest their therapeutic potential in autoimmune diseases. However, the effects of MSC on B cells are still poorly understood. The present study was designed to investigate the interaction between MSC and ...