The apical membrane is an important site of mercury toxicity in shark rectal gland tubular cells. We compared the effects of mercury and other thiol-reacting agents on shark CFTR (sCFTR) and human CFTR (hCFTR) chloride channels using two-electrode voltage clamping of cRNA microinjected Xenopus laevis oocytes. Chloride conductance was stimulated by perfusing with 10 microM forskolin (FOR) and 1 ...

Both alkylarylalkynes and diarylalkynes 1 are converted into the α-diketones 2 in good yield by the use of mercuric salts, e.g., mercuric nitrate hydrate or mercuric triflate, in the presence of water. Other mercuric salts, e.g., sulfate, chloride, acetate, or trifluoroacetate, do not provide the diketone product. A possible mechanism is proposed.

introduction: aluminum is known as a neurotoxic element which causes neurodegeneration, learning deduction and movement disorders. aluminum ions in the brain cause serious problems such as alzheimer, parkinson and other degenerative diseases. on the other hand, zinc is a dietary element essential for several biological processes, modulates neurotransmission in brain regions and associates with ...

With the advent of modern ophthalmic treatment the use of mercury preparations in ophthalmology has almost been relegated to past history, but mercurous chloride (calomel) is still occasionally used as an insufflation into the eyes, especially in such conditions as phlyctenular keratoconjunctivitis. Recently we saw a case wherein mercuric chloride (HgCl2) was mistaken for calomel and dusted int...

Introduction: Aluminum is known as a neurotoxic element which causes neurodegeneration, learning deduction and movement disorders. Aluminum ions in the brain cause serious problems such as Alzheimer, Parkinson and other degenerative diseases. On the other hand, Zinc is a dietary element essential for several biological processes, modulates neurotransmission in brain regions and associates wi...

because microaspiration of contaminated supraglottic secretions past the endotracheal tube cuff is considered to be central in the pathogenesis of pneumonia, improved design of tracheal tubes with new cuff material and shape have reduced the size and number of folds, which together with the addition of suction ports above the cuff to drain pooled subglottic secretions leads to reduced aspiratio...

The organomercurial, thimerosal, is at the center of medical controversy as a suspected factor contributing to neurodevelopmental disorders in children. Many neurotoxic effects of thimerosal have been described, but its interaction with principal excitatory and inhibitory neurotransmiter systems is not known. We examined, using electrophysiological recordings, thimerosal effects on GABA and NMD...