Melatonin and migraine have been linked in most ways, from mechanisms to treatment. Migraine is one of the common neurological diseases it characterized by throbbing unilateral headache attacks. an issue for both individuals society. can lead reduced work productivity a flawed family social life. It has suggested that melatonin plays key therapeutic role treating migraines several other types h...

Exacerbation of certain medical conditions at specific phases of the menstrual cycle is a well-recognized phenomenon. We review the effects of the menstrual cycle on medical conditions, including menstrual migraine, epilepsy, asthma, rheumatoid arthritis, irritable bowel syndrome, and diabetes. We discuss the role of medical suppression of ovulation using gonadotropin-releasing hormone agonists...

OBJECTIVE Migraine is a disease of high prevalence with important impact on people's daily activities. The study aimed at assessing the distribution of migraine in adult population and some of its determinants. METHODS A cross-sectional population-based study was conducted with a multi-stage and probabilistic sampling. A total of 2,715 individuals aged 20 to 64 years old living in the urban a...

OBJECTIVES The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP expre...

Migraine is defined as recurrent attack of headache that are commonly unilateral and accompanied by gastrointestinal and visual disorders. Migraine is more prevalent in females than males with a ratio of 3:1. It is primarily a complex neurovascular disorder involving local vasodilation of intracranial, extracerebral blood vessels and simultaneous stimulation of surrounding trigeminal sensory ne...