Correspondence to: Dr M Langran, Aviemore Health Centre, Muirton, Aviemore PH22 1SY, UK; [email protected] _________________________ T he vast majority of skin problems that present in the community are minor in nature. Unfortunately, very occasionally, the development of seemingly innocuous symptoms such as a rash and/or itching can be the presenting symptoms of a life threatening condition—...

A Vasculite associada à imunoglobulina (VIgA), também conhecida como púrpura de Henoch-Schonlein, anafilactóide ou reumática é uma vasculite pequenos vasos a deposição imunocomplexos IgA,de etiologia ainda desconhecida e que acomete principalmente crianças. Em grande parte dos casos pediátricos, doença autolimitada com manifestações cutâneas, articulares, gastrintestinais renais. O diagnóstico ...

Purpura fulminans (PF) is an ominous cutaneous condition usually associated with meningococcemia. PF in the newborn is rarely reported. We report the case of a female preterm infant with extensive PF due to group B streptococcus (GBS) septicemia. She developed multi-organ system failure despite neonatal intensive care support and succumbed 9 days later. GBS, sensitive to penicillin, was isolate...

Activated protein C (APC) is a natural anticoagulant that plays a pivotal role in coagulation homeostasis. Severe inherited or acquired deficiency results in a clinical syndrome called purpura fulminans. In addition, APC also appears to have potent cytokine-modifying properties and is protective in animal models of sepsis. The dual functional properties of APC are particularly relevant to sever...