Melioidosis is a disease caused by bacteria called B. pseudomallei. Infections can develop after contact with standing water. This disease can reach all the organs and especially the lungs. It is associated with a high mortality rate (up to 50%). Melioidosis is endemic in northern Australia and in Southeast Asia. Nevertheless, B. pseudomallei may be endemic in the Indian Ocean region and in Mad...

Melioidosis is a suppurative chronic infection caused by a gramnegative bacterium, Burkholderia pseudomallei. We report two patients who presented with isolated liver abscesses caused by this pathogen. Both patients presented with high-grade fever and abdominal pain. On examination they were toxic and had tender hepatomegaly. Investigations showed leucocytosis and a shift to the left. Early dia...

Pneumonia is a common manifestation of the potentially fatal disease melioidosis, caused by the select agent bacteria Burkholderia pseudomallei. In this study we describe a new model system to investigate pulmonary melioidosis in vivo using bioluminescent-engineered bacteria in a murine respiratory disease model. Studies were performed to validate that the stable, light producing B. pseudomalle...

Melioidosis (Burkholderia pseudomallei infection) is a common cause of community-acquired sepsis in Northeast Thailand and northern Australia. B. pseudomallei is a soil saprophyte endemic to Southeast Asia and northern Australia. The clinical presentation of melioidosis may mimic tuberculosis (both cause chronic suppurative lesions unresponsive to conventional antibiotics and both commonly affe...

Melioidosis results from an infection with the soil-borne pathogen Burkholderia pseudomallei, and cases of melioidosis usually cluster after rains or a typhoon. In an endemic area of Taiwan, B. pseudomallei is primarily geographically distributed in cropped fields in the northwest of this area, whereas melioidosis cases are distributed in a densely populated district in the southeast. We hypoth...

Urokinase receptor (urokinase-type plasminogen activator receptor [uPAR], CD87), a GPI-anchored protein, is considered to play an important role in inflammation and fibrinolysis. The Gram-negative bacterium Burkholderia pseudomallei is able to survive and replicate within leukocytes and causes melioidosis, an important cause of pneumonia-derived community-acquired sepsis in Southeast Asia. In t...

Melioidosis is a life-threatening infection caused by Burkholderia pseudomallei, an environmental Gram-negative bacterium, inhabitant of moist soils in the tropics and subtropics. There no licensed vaccine against melioidosis. The main routes B. pseudomallei are percutaneous inoculation, inhalation, or ingestion. Individual cases vertical, sexual, zoonotic, nosocomial transmission melioidosis d...

Melioidosis (Whitmore’s disease) is an emerging disease caused by the Gram-negative saprophyte bacterium Burkholderia pseudomallei. It a common but sometimes neglected zoonotic with wide range of hosts, including humans. has emerged as leading cause morbidity and mortality in tropical countries, such Thailand, northern Australia, etc., continually on wider geographical scale. Recent epidemiolog...

We commend Suntornsut and others for reminding us that pulmonary melioidosis should be considered in every patient with a tuberculosis (TB)–like chest radiographic result and negative acid-fast bacilli (AFB) smears in melioidosisendemic countries, such as Thailand. This finding confirms the conclusion we drew from our analysis of a series of pulmonary melioidosis cases in neighboring Cambodia. ...