The incidence of skin cancer has been rising at an astonishing rate, particularly that of the deadliest skin cancer, melanoma. While the molecular mechanisms of sunlight ultraviolet radiation (UV)-induced non-melanoma skin cancer (NMSC) have been well documented, there is a major gap in our current knowledge of how UV initiates melanoma. However, the components of the retinoblastoma (Rb) pathwa...

Background: The most common types of non-melanoma skin cancer are basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). AKIEC -Actinic keratoses (Solar keratoses) and intraepithelial carcinoma (Bowen’s disease)- are common non-invasive precursors of SCC, which may progress to invasive SCC, if left untreated. Due to the importance of early detection in cancer treatment, this study aimed...

To improve accuracy of localize suspicious lesion region in dermatoscopic images using Region Growing, the initial step based on fuzzy sets to enhance the lesion region of interest (ROI) is developed. The result of skin lesion detection is used to extract Asymmetry, Border Irregularity, Color Variation, Diameter (ABCD) features for melanoma skin cancer diagnosis. ABCD feature is the rule that i...

Skin cancers are cancers that due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. There are three main types: basal-cell cancer, squamous-cell cancer and melanoma. Among the three melanoma spreads through metastasis, and therefore it has been proved to be very fatal. Melanomas typically occur in the skin and identification of skin cance...

Human melanoma is the fastest growing cancer currently in USA and worldwide. Melanoma accounts for 5% of all skin cancers but 71% of all skin cancer deaths. The risk for melanoma has steadly increased since 1935 when the risk was 1:1,500. Today one in 74 people are diagnosed with melanoma. The mechanism for melanoma initiation is unknown and no significant advances in medical therapies (surviva...

Commercially available clinical decision support systems (CDSSs) for skin cancer have been designed for the detection of melanoma only. Correct use of the systems requires expert knowledge, hampering their utility for nonexperts. Furthermore, there are no systems to detect other common skin cancer types, that is, nonmelanoma skin cancer (NMSC). As early diagnosis of skin cancer is essential, th...

Melanoma is a malignancy of melanocytes or pigment-producing cells located predominantly in the skin. It is less common than other skin cancers but causes the greatest number of skin cancer-related deaths worldwide. The incidence of melanoma continues to increase and early detection is the most promising means of decreasing morbidity and mortality. Currently, physicians perform routine skin can...

Skin cancer is the most common cancer in the Western world. In order to accurately detect the disease, especially malignant melanoma-the most fatal form of skin cancer-at an early stage when the prognosis is excellent, there is an urgent need to develop noninvasive early detection methods. We believe that polarization speckle patterns, defined as a spatial distribution of depolarization ratio o...

Although malignant melanoma is a rare type of skin cancer, it accounts for most cancer-related deaths. Foot lesions may be ignored by both patients and clinicians could therefore lead to advanced disease. An acral also confused with pressure ulcer result in late diagnosis. The need perform biopsy should considered when dealing protracted wounds. In this report, we present the case an 84-year-ol...