نتایج جستجو برای: meg3
تعداد نتایج: 407 فیلتر نتایج به سال:
Fetal growth restriction (FGR) is the failure of fetus toachieve its genetically determined potential, which increasesrisks for a variety genetic diseases, such as type 2 diabetes mellitus, coronary artery disease, and stroke, during lifetime. The dysregulation DNA methylationis known to interact with environmental fluctuations, affect gene expressions comprehensively, be fatal development in s...
The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains IG-DMR and Gtl2-DMR, whose methylation patterns are established in the germline and after fertilization, respectively. In this study, we determine that acquisition of DNA methylation at the paternal allele of the Gtl2-DMR is initiated after the blastocyst stage and completed by embryonic day 6.5, and that Gtl2 (approved symbol: Meg3...
BACKGROUND Genomic imprinting is an exception to Mendelian genetics in that imprinted genes are expressed monoallelically, dependent on parental origin. In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is implicated in several diseases including Prader-Willi/Angelman syndromes and cancer. METHODOLOGY/PRINCIPAL F...
Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. In the present study, lncRNA and mRNA expression profiling of...
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