High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in...

Recently we showed how crystallization in microemulsions could lead directly to the most stable polymorph, thereby leapfrogging Ostwald’s rule of stages. Here we consider in more details the crystallization of mefenamic acid from dimethylformamide microemulsions. Crystallization of mefenamic acid from bulk DMF has previously been shown to produce only the metastable Form II irrespective of the ...

Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid relapse.

Mefenamic acid is characterized by a low oral bioavailability due to its slow dissolution and absorption. The purpose of this study was investigate the effect salt formation on mefenamic physical stability. Potassium, sodium lysine salts were prepared. resulting formed scanning electron microscopy, hot-stage Fourier transform infrared spectroscopy, differential calorimetry powder X-ray diffract...

Herbal remedies in therapy have been used the treatment of pain since time immemorial. Pain is a sensory and emotional event that causes discomfort due to tissue damage. Most analgesics modern medicine side effects on either gastro-intestinal tract or nervous system. Empirically waru leaves as traditional medicine. The purpose this study was evaluate analgesic effect ethanol extract leaf compar...

Abstract The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain. The present study was designed to investigate the effect of 5 non-steroidal anti-inflammatory drugs, sodium salicylate, phenylbutazone, indomethacin, ibuprofen and mefenamic acid, on seizures produced by pilocarpine. Pretreatment of rats with so...