Caroline F. Thorn(1), Yuan Ji(2), Richard M. Weinshilboum(2), Russ B. Altman(1),(3), and Teri E. Klein(1) (1)Department of Genetics, Stanford University Medical Center, Stanford, CA, USA (2)Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA (3)Department of Bioengineering, Stanford University Medical Cent...

From the Thoracic Oncology and Experimental Therapeutics Programs at the H.Lee Moffitt Cancer Center & Research Institute, Tampa, Fla (EBH), the Department of Pathology at Baylor University Medical Center, Dallas, Texas (MAW), the Department of Pathology at Duke University Medical Center, Durham, NC (ADP), and the Division of Gastroenterology/Hepatology at the University of Colorado Health Scie...

Experimental Therapeutics Program, Division of Medical Oncology, College of Physicians and Surgeons of Columbia University, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Department of Neurosurgery,Neurologic Institute of New York, Columbia University Medical Center, N.Y. 10032, Department of Chemistry, College of Staten Island, 2800 Victory...

composite Impregnated with Bone Morphogenetic Protein-2 Takashi Taniyama, Shinichi Sotome, Tsuyoshi Yamada, Tomokazu Masaoka, Toshitaka Yoshii, Tomoji Takayama, Yuko Kozaka, Takehiko Nakajima, Atsushi Okawa. Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan, Development Division of Advanced Orthopaedic Therapeutics, Graduate School, Tokyo Medical and Dental Un...

1Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada 2Department of Biochemistry & Molecular Biology, 3Department of Clinical Neurosciences, and 4Department of Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta T2N 1N4, Canada 5Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands 6Department of Immunology, Tehran Univers...

Molecular Cardiology Rsrch Inst Ctr for Translational Genomics, Dept of Medicine, Cardiology Division, Tufts Medical Ctr, Boston, MA;Dept of Medicine, Division of Cardiovascular Diseases, Dept of Molecular Pharmacology & Experimental Therapeutics, Dept of Pediatric & Adolescent Medicine/Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN;Dept of Medicine, Duke University Medical Center...

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

orofacial granulomatosis(ofg) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissues swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. ofg may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. the...

concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. although these recommendations are not specific to children, the values can be extrapolated. this prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...