Cohesion is an important aspect of English texts, and to achieve that, writers utilize certain devices known as Discourse Markers (DMs). This study thus sought analyze the discussion section 12 research articles (RAs) published on two different journals (i.e., Language Teaching Research American Journal Medical Genetics Part B: Neuropsychiatric Genetics) which cover contrastive disciplines huma...

Background and Aim: Stress has been associated with recurrent aphthous stomatitis (RAS). The common treatment of RAS is a topical steroid. This study aimed to investigate the difference of salivary cortisol between RAS patients treated with a topi-cal steroid and those without treatment. Materials and Methods: Thirty-two female patients with RAS participated in this case-control study and were...

BACKGROUND Many studies suggest a major prevalence of atherosclerotic renovascular disease (ARVD), caused by mono or bilateral renal artery stenosis (RAS). Unfortunately, there is no definite therapy to cure this disease to date; therefore, ARVD is burdened by important clinical complications with high social and economic costs. The last few years have seen important advancements in both medica...

Acquired aplastic anemia (AA), characterized by pancytopenia in peripheral blood (PB) and bone marrow (BM) hypoplasia, is a bone marrow failure syndrome. The late evolution to myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML) is the most common clonal complication in refractory patients and in those who do not achieve a robust response. The reported rates of clonal evolution varied i...

The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exerci...

Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Rare Anaemias (RA) are a group of Rare Diseases (RD) with prevalence, in Europe, less than 5 per 10.000 individuals. Major forms of RAs require red blood cell transfusions, iron chelation, splenectomy, and/or in very severe cases, bone marrow transplantation, as main therapeutic options. Beta-thalassaemia major...

The modern intensive care unit (ICU) has become a complex, expensive, data-intensive environment. Caregivers maintain an overall assessment of their patients based on important observations and trends. If an advanced monitoring system could also reliably provide a systemic interpretation of a patient’s observations it could help caregivers interpret these data more rapidly and perhaps more accu...

Despite the biological and medical importance of signal transduction via Ras proteins and despite considerable kinetic and structural studies of wild-type and mutant Ras proteins, the mechanism of Ras-catalyzed GTP hydrolysis remains controversial. We take a different approach to this problem: the uncatalyzed hydrolysis of GTP is analyzed, and the understanding derived is applied to the Ras-cat...