The Mars Environmental Dynamics Analyzer instrument on 2020 has five Atmospheric Temperature Sensors at two altitudes (0.84 and 1.45 m) plus a Thermal InfraRed Sensor that measures temperatures the surface ∼40 m. We analyze measurements from these sensors to describe evolution of in Jezero up mission sol 400 (solar longitude LS = 13°–203°). diurnal thermal cycle is characterized by daytime conv...

Visha possess properties of Vyavayi(Pervading or diffusing action), Vikasi(Dispersed through out the body causes destruction Ojas and Dhatu Kshaya depletion tissues, Ushna(Heat), Teekshna(Penetrating), Ruksha(Dry), Sukshma(Minuteness), Ashukar(Quick immediate Vishada(Clearness), Laghu(Light), Avyakta Ras(Taste sometimes palatable not taste is hidden) Apaki(Not digestible). It distributes in who...

For the first time, the partition coefficients of the ionized forms of several opioids, amphetamine-like drugs, and their metabolites were determined by studying their ionic transfer process across the bare interface water/organic solvent. The ionic partition coefficients of the monocationic forms of 12 compounds--heroin, 6-monoacetylmorphine (6-MAM), morphine, acetylcodeine, codeine, dihydroco...

This article describes a comprehensive testing method for the thermal calibration of Thermal InfraRed Sensor (TIRS) onboard NASA's Perseverance rover. Ground-based IR detectors operating at surface Mars are subjected to inaccuracies caused by inclusion gradients in their packages. To reduce such uncertainties, it is necessary compensate effects. Here, details TIRS thermo-mechanical design and s...

Recently, the European Medicines Agency (EMA) published the new draft guideline on the pharmacokinetic and clinical evaluation of modified release (MR) formulations. The draft guideline contains the new requirement of performing multiple dose (MD) bioequivalence studies, in the case when the MR formulation is expected to show 'relevant' drug accumulation at steady state (SS). This new requireme...

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is...