Mechanochemical synthesis has recently emerged as a scalable “green” approach for the preparation of MOFs, but current understanding underlying reaction mechanisms is limited. In this work, an investigation pathway mechanochemical MOF-74 from ZnO and 2,5-dihydroxyterephthalic acid (H4HDTA), using DMF liquid additive, presented. The complex involves formation four short-lived intermediate phases...

Copper-catalyzed mechanochemical click reactions using Cu(II), Cu(I) and Cu(0) catalysts have been successfully implemented to provide novel 6-phenyl-2-(trifluoromethyl)quinolines with a phenyl-1,2,3-triazole moiety at O-4 of the quinoline core. Milling procedures proved to be significantly more efficient than the corresponding solution reactions, with up to a 15-fold gain in yield. Efficiency ...