Skin perfusion pressure (SPP) is the perfusion pressure at the skin level, and it can serve as an index of peripheral circulation in the skin and subcutaneous tissue. We report a 78-year-old man with critical limb ischaemia who, despite having undergone several catheter interventions, still had severe ulcers with exposed bone on his right foot. We performed transmetatarsal amputation. The tissu...

-methyldithiophene-tetrathiafulvalene (-mDT-TTF), the first alkyl substituted thiophenic-TTF electronic donor, as well as some of its charge transfer salts are reported. The crystal structure of -mDT-TTF is composed of molecular stacks aligned parallel to each other. Its cyclic voltammetry shows higher electron donor ability than the unsubstituted analogue -DT-TTF. This material has been em...

The stabilization of switched linear systems with constrained inputs (SLSCI) is considered. The authors design admissible linear state feedbacks and the switching rule which has a minimal dwell time (MDT) to stabilized the system. First, for each subsystem with constrained inputs, a stabilizing linear state feedback and an invariant set of the closed-loop system are simultaneously constructed, ...

The degree of charge transfer and the upper critical field of the organic superconductor ~MDT-TSF!(AuI2)x have been investigated ~MDT-TSF: methylenedithio-tetraselenafulvalene!. The x-ray oscillation photograph indicates that the anion lattice is incommensurate with the donor lattice, and the chemical composition is ~MDT-TSF!(AuI2)0.44 . The charge-transfer degree of this salt is 0.44. The elec...

Aware of the world-wide concern about the dapsone monotherapy problem, the National TB-Leprosy Programme (NTLP) has gradually introduced the multiple drug (MDT) treatment of leprosy in its activities . The programme as most of the delegates will recall started in July 1 977, and 3 years later MDT was started in some patients thought to be resistant to dapsone . Since then, the number of patient...

BACKGROUND Leprosy reactions are a major cause of disability before, during and after anti-bacterial treatment. Prompt diagnosis and correct management of reaction is a crucial matter for improving the quality of leprosy health services. OBJECTIVES To describe the pattern of leprosy reaction and its management in China during 2005. METHODS A retrospective survey using a questionnaire was ca...

Bacterial populations produce persisters, cells that neither grow nor die in the presence of bactericidal agents, and thus exhibit multidrug tolerance (MDT). The mechanisms of MDT and the nature of persisters have remained elusive. Our previous research has shown that persisters are largely responsible for the recalcitrance of biofilm infections. A general method for isolating persisters was de...

INTRODUCTION The WHO MDT for leprosy treatment was officially introduced in Brazil in 1991 and comprises three drugs: dapsone, rifampicin and clofazimine. There are few good studies on the frequency of side-effects attributable to MDT in Brazil. METHODS A retrospective and descriptive study carried out in a LCP in Vitória, State of Espirito Santo, Brazil. A specific and detailed protocol abou...

This study looked at the integration of leprosy services in the GHS in context of health and socioeconomic situations using predefined indicators. It also looked at clients' perception of MDT services. The Indian states of Chhattisgarh and Kerala, which are at two extremes in leprosy endemicity, health situation and socioeconomic development, have been compared using predefined integration indi...

UNLABELLED We conducted randomized double-blind trial for single-dose of Rifampicin, Ofloxacin and Minocycline (ROM) compared to WHO-PB-MDT among paucibacillary (PB) leprosy patients with 2-5 skin lesions. We enrolled 1526 patients from five centres (ROM=762; WHO-PB-MDT=764) and followed them for 36 months posttreatment during 1998-2003. We generated information on clearance of skin lesions and...