Topic models have been widely used to identify topics in text corpora. It is also known that purely unsupervised models often result in topics that are not comprehensible in applications. In recent years, a number of knowledge-based models have been proposed, which allow the user to input prior knowledge of the domain to produce more coherent and meaningful topics. In this paper, we go one step...

As the CA1 sector has been implicated to play a key role in memory formation, a dedicated search for highly expressed genes within this region was made from an on-line atlas of gene expression within the mouse brain (GENSAT). From a data base of 1013 genes, 16 were identified that had selective localization of gene expression within the CA1 region, and included Angpt2, ARHGEF6, CCK, Cntnap1, DR...

Let Nσ(π) denote the number of occurrences a permutation pattern σ∈Sk in π∈Sn. Gaetz and Ryba [3] showed using partition algebras that d-th moment Mσ,d,n(π) Nσ on conjugacy class π is given by polynomial n,m1,…,mdk, where mi denotes i-cycles π. They also coefficient 〈χλ[n],Mσ,d,n〉 agrees with aσ,dλ(n) n. This work motivated conjecture when σ=idk identity permutation, all these coefficients are ...

Martina Bögel, Weinmann GmbH, Hamburg Andreas Bosch, Heinen & Löwenstein GmbH, Bad Ems Jörg Brambring, Heimbeatmungsservice Brambring Jaschke GmbH, Unterhaching Stephan Budweiser, Klinik Donaustauf Dominic Dellweg, Fachkrankenhaus Kloster Grafschaft GmbH, Schmallenberg Peter Demmel, MDK Bayern, München Rolf Dubb, Klinikum Stuttgart – Katharinenhospital Jens Geiseler, Asklepios Fachkliniken Münc...

Tumor infiltrating immune cells (TIICs) interact with tumor to influence development and progression. However, how the interaction between melanoma TIICs affects invasion metastasis of in congenital melanocytic nevus (CMN) is largely unknown. We analyzed multiple samples including various regions different depths metastatic tissues from two patients identified differential gene expression profi...

Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in whichMYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic gangl...

The incidence of pancreatic ductal adenocarcinoma (PDAC) nearly equals its mortality rate, partly because most PDACs are intrinsically chemoresistant and thus largely untreatable. It was found recently that chemoresistant PDAC cells overexpress the Notch-2 receptor and have undergone epithelial-mesenchymal transition (EMT). In this study, we show that these two phenotypes are interrelated by ex...

As it has been demonstrated previously that midkine (also known as neurite growth-promoting factor 2) protein levels in urine of bladder cancer (BCa) patients are increased compared to healthy controls, the present study validated the diagnostic utility of midkine in an independent patient cohort and compared the observed values with voided urine cytology (VUC), which is the current reference s...