One of the open issues in Model Driven Architecture (MDA) is how to automatically transform the Platform Independent Model (PIM) over the Platform Specific Model (PSM) into source code currently this is only possible for a few domains using UML profiles, but the major goal is to minimize the required interaction by the programmer / designer at these steps in the general case. The idea is to def...

MDA wird als Zukunft des Software Engineering dargestellt. Trotz positiver Erfahrungsberichte vertreten wir die Auffassung, dass noch ein weiter Weg vor uns liegt, bis MDA in großem Maßstab eingesetzt wird. Dies ist bedingt durch die heute noch unbefriedigenden Möglichkeiten zur Dynamikmodellierung in UML. Wir präsentieren ein Architekturprinzip, das die von MDA postulierte Trennung von Anwendu...

Malondialdehyde (MDA) is a natural and widespread genotoxin. Given its potentially deleterious effects, it is of interest to establish the identities of the cell types containing this aldehyde. We used in situ chemical trapping with 2-thiobarbituric acid and mass spectrometry with a deuterated standard to characterize MDA pools in the vegetative phase in Arabidopsis thaliana. In leaves, MDA occ...

This position paper reports on an initial investigation in the fields of MDA and generative approaches. Our view is that MDA aims at providing a precise framework for generative software production. Unfortunately many notions are still loosely defined (PIM, PSM, etc.).. We propose here an initial exploration of some basic artifacts of the MDA space. Because all these artifacts may be considered...

The paper presents Ontology Definition Metamodel (ODM) and Ontology UML Profile that enables using Model Driven Architecture (MDA) standards in ontological engineering. Other similar metamodels are based on ontology representation languages, such as RDF(S), DAML+OIL, etc. However, none of these other solutions uses the recent W3C effort – The Web Ontology Language (OWL). In our approach, we fir...

4 Wagner JC. Asbestos dust exposure and malignancy. Proceedings of 14th congress on occupational health. Madrid: 1963. 5 Hourihane DO'B, Lessof L, Richardson PC. Hyaline and calcified pleural plaques as an index of exposure to asbestos. A study of radiological and pathological features of 100 cases with the consideration of epidemiology. Biological monitoring of MDA Sir,-4,4'-methylenedianiline...

In this report, we describe the case of a patient who has remained in a comatose state for more than one year after a traumatic and hypoxic brain injury. This state, which we refer to as long-lasting coma (LLC), may be a disorder of consciousness with significantly different features from those of conventional coma, the vegetative state, or brain death. On the basis of clinical, neurophysiologi...

α-Synuclein (α-syn) plays a prominent role in the degeneration of midbrain dopaminergic (mDA) neurons in Parkinson's disease (PD). However, only a few studies on α-syn have been performed in the mDA neurons in vivo, which may be attributed to a lack of α-syn transgenic mice that develop PD-like severe degeneration of mDA neurons. To gain mechanistic insights into the α-syn-induced mDA neurodege...

In the present study we show that histone deacetylase inhibitors (HDACIs) enhance the anti-tumor effects of melanoma differentiation associated gene-7/interleukin 24 (mda- 7/IL-24) in human renal carcinoma cells. Similar data were obtained in other GU tumor cells. Combination of these two agents resulted in increased autophagy that was dependent on expression of ceramide synthase 6, with HDACIs...

The Model Driven Architecture (MDA) involves automated transformations between software models defined in different languages at different abstraction levels. This paper takes an MDA approach to integrate a formal modeling language (Object-Z) with an informal modeling language (UML) via model transformation. This paper shows how formal and informal modeling languages can be cooperatively used i...