This article describes the use of a combination of extended-connectivity fingerprints (ECFPs) and Laplacian-modified Bayesian analysis in a study of the inhibition of Escherichia coli dihydrofolate reductase. The McMaster High-Throughput Screening Lab at McMaster University proposed a competition to predict the hits in a separate test set of 50,000 compounds. Although the problem seemed best ap...

1Department of Medicine, University of Western Ontario, 339 Windermere Road, London, ON, Canada N6A 5A5 2Division of Endocrinology and Metabolism, St. Joseph’s Hospital, 268 Grosvenor Street, London, ON, Canada N6A 4V2 3Department of Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 4Department of Medicine, McMaster University, 1280 Main St...

The objective of this study was to perform the comparative evaluation of efficiency of traditional McMaster chamber and the newly designed chamber for the enumeration of nematode eggs in different agriculture animals. Thirteen pig, two horse and two sheep farms were randomly selected, and 815 of pig faecal samples, 264 of horse and 264 of sheep faecal samples were examined. The positive samples...

Dr. Grunfeld is Professor of Medicine, Dalhousie University, and Director of Health Services and Outcomes Research, Cancer Care Nova Scotia, Halifax, NS. Dr. DhesyThind is with the Cancer Care Ontario Juravinski Regional Cancer Centre and is Assistant Professor in the Department of Medicine, McMaster University, Hamilton, Ont. Dr. Levine is Professor in the Departments of Clinical Epidemiology ...

Martin D. Bootman,1,2,5 Katja Rietdorf,3 Tony Collins,4 Simon Walker,1 and Michael Sanderson3 Babraham Institute, Babraham, Cambridge, CB22 3AT, United Kingdom; Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom; Department of Microbiology and Physiology Systems, University of Massachusetts Medical School, Worcester, Massac...

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK AstaZeneca R&D, Mölndal, Sweden Department of Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden AstraZeneca LP, Wilmington, DE, USA Duke University Medical Center, Durham, NC, USA HGM-McMaster Clinic, Hamilton, Ontario, Canada Department of Emergency and Cardiovascular Medicine, Sahlgrenska...

Assistant Professor, Department of Clinical Epidemiology & Biostatistics, and Adjunct Faculty, McMaster Health Forum, McMaster University, Hamilton, Ontario, Canada, Research Fellow, Global Health Diplomacy Program, Munk School of Global Affairs, University of Toronto, Ontario, Canada, Fulbright & Knox Fellow, Interfaculty Initiative in Health Policy, Harvard University, Cambridge, MA, USA, Dea...