Female sexual behavior in rodents, termed lordosis, is controlled by facilitatory and inhibitory systems in the brain. It has been well demonstrated that a neural pathway from the ventromedial hypothalamic nucleus (VMN) to the midbrain central gray (MCG) is essential for facilitatory regulation of lordosis. The neural pathway from the arcuate nucleus to the VMN, via the medial preoptic nucleus,...

Forty male Polynesian W. bancrofti carriers with mf counts greater than or equal to 20/ml were treated with a single ivermectin 50, 100, 150 or 200 mcg/kg dose. Following therapy, mf levels fell to less than 1% of pretreatment levels in the carriers treated with the 3 highest doses. After one month, negativation rate was 40% in patients treated with a 50 mcg/kg dose, significantly lower than in...

BACKGROUND Mountain-cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to Panax ginseng and have similar ingredients. However, their pharmacological activities are different due to their significantly different growth environments. METHODS An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-based approach was developed to dist...

Magnetocardiography is the recording of magnetic field (MF) generated by cardiac electrophysiological activity. Being a contactless method, magnetocardiography is ideal for non-invasive cardiac mapping of small experimental animals. The aim of this study was to assess age-related changes of cardiac intervals and of ventricular repolarization (VR) maps in intact rats, by means of magnetocardiogr...

Background.  We evaluated the safety and immunogenicity of VAX2012Q, a quadrivalent influenza vaccine comprising 4 hemagglutinin subunits fused to flagellin. Methods.  In this dose-ranging, open-label study, healthy adults (18-40 years) were divided into 7 cohorts for evaluation of 5 dose levels and 3 component ratios. Dose levels were as follows: (1) 1 mcg per component of VAX128C (H1N1), VAX1...

The exposure of the macrophage cell line, J774 to mast cell granules (MCG) led to the formation of altered nuclear transcription factor proteins (NF-kappaBx), which had faster electrophoretic mobility than the p50 homodimer of NF-KB, but retained comparable DNA binding capacity. Antibodies to N-terminal peptides of p50, p52, p65 or c-Rel supershifted only a fraction of NF-kappaBx. Western blot ...

Case description A ten-year-old boy with asthma, peanut allergy, and allergic rhinitis had been maintained on a regimen of FP/salmeterol 500 mcg per day and mometasone furoate nasal spray 50 mcg per day. During exacerbations FP 500 mcg per day was added. He had no oral steroid usage. After a stable period with only FP/salmeterol, his regimen was changed to BUD/formoterol 800 mcg per day. Shortl...

QT dispersion is defined as the difference between the maximum QT and minimum QT intervals on standard 12-lead electrocardiogram (ECG). It is a new index of the homogeneity of ventricular repolarization and considered to be a marker for the risk of malignant ventricular arrhythmia [1, 2]. There have been, however, no detailed studies except in myocardial infarction on QT dispersion using magnet...

BACKGROUND Crohn's disease (CD) and multiple sclerosis (MS) share common pathogenic processes. Interferon (IFN) beta-1a is effective and generally well tolerated in patients with MS and has been shown to down-regulate the expression of interleukin-12, a cytokine that is thought to be involved in mucosal degeneration in CD. IFN beta-1a therefore offers promise as a treatment for CD. METHODS In...

BACKGROUND Inhaled glucocorticosteroids (ICS) are the mainstay of treatment in asthma. Fluticasone furoate (FF) is a novel, once-daily ICS asthma therapy. This study investigated the efficacy and safety of FF 50 mcg in patients with mild-to-moderate persistent asthma. METHODS A 24-week, multicenter, randomized, placebo-controlled and active-controlled, double-blind, double-dummy, parallel-gro...