An improved proportionate adaptive filter based on the Maximum Correntropy Criterion (IP-MCC) is proposed for identifying the system with variable sparsity in an impulsive noise environment. Utilization of MCC mitigates the effect of impulse noise while the improved proportionate concepts exploit the underlying system sparsity to improve the convergence rate. Performance analysis of the propose...

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with frequent metastasis and death. MCC has a mortality rate of 30%, making it more lethal than malignant melanoma, and incidence of MCC has increased almost fourfold over the past 20 years in the USA. MCC has long been considered to be an immunogenic cancer because it occurs more frequently in immunosuppressed patients from organ...

BACKGROUND Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. The present study aimed to identify novel oncogenes involved in malignant transformation of TRAF3-deficie...

BACKGROUND MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle-type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP) channels and mitochondrial K(ATP) (mitoK(ATP)) channels are unknown. A mixed agonist/blocker wit...

Workstation processing power and the number of available workstation application tools have increased dramatically in the last five years. Sophisticated users now find that "real work" can be accomplished on CAD/CAE workstations. In "Conversion of an IC Design Capability from a Mainframe to a Workstation Environment," Dave Palmer and John Wisniewski from Sandia National Laboratories recount the...

Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients. Recently, the clonal integration of a new human polyoma virus, which was termed Merkel cell polyomavirus (MCPyV), has been reported in 8 of 10 MCC patients. In the present study, we studied the formalin-fixed and paraffin-embedded tissue specimens of 39 MCC for the presence of...

INTRODUCTION Chronic diseases constitute a major public health challenge. The prevalence of multiple chronic conditions (MCC) has increased. The objective of our study was to describe the prevalence, correlates, and time trends of MCC in the Israeli population and among the nation's 2 main population groups (Jewish and Arab). METHODS To describe the prevalence of correlates of MCC, we used da...

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy. The infectivity of Merkel cell polyomavirus (MCPyV), an apparent agent in MCC development, may be exacerbated with impaired immune responses. This paper reviews relevant data regarding the role of immunosuppression in the development of MCC and describes modes of immunodeficient states. Because of the inherently low inci...

Taiwanese Sign Language (TSL) is the natural language among deaf communities in Taiwan. Manually Coded Chinese (MCC) is the official instructional language. Previous studies have shown that the deaf students have great difficulty in comprehending stories in MCC, plausibly due to greater word length in MCC, which in turn may impair recall of MCC words. In Study I, deaf and hearing signers produc...

The mitotic (or spindle assembly) checkpoint system prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of chromosome segregation. Kinetochores that are not attached properly to the mitotic spindle produce an inhibitory signal that prevents progression into anaphase. The checkpoint system acts on the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ...