نتایج جستجو برای: mbl2
تعداد نتایج: 273 فیلتر نتایج به سال:
Background. Infectious complications remain a serious threat to polytraumatized patients. Susceptibility and response to infection is, in part, heritable. The lectin pathway plays a major role in innate immunity. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) in three key genes within the lectin pathway affect susceptibility to infectious complications in severely...
Functional deficiency of mannan-binding lectin (MBL) has been associated with adverse pregnancy outcome. Adverse events during pregnancy have also been described in women with autoimmune thyroid diseases (AITD), and thyroid hormones have been shown to influence serum levels of MBL. Therefore, the aim of this study was to analyse the impact of MBL-deficiency on the outcome of pregnancy in relati...
BACKGROUND Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis. METHODS We reanalyzed MBL results in a large cohort with use of individual data from 4 studies inv...
OBJECTIVE MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes. RE...
Adresa za dopisivanje Professor Renata Cimões Av Prof. Moraes Rego 1235 Ciudade Universitária Recife-PE, Brazil. 50670-901. Tel. (55) 81 2126-8817 Fax. (55) 2126-8836 [email protected] Sažetak Svrha: Lektin koji veže manozu (MBL) važan je protein urođenog imunološkog sustava. Sposoban je vezati se za šećerne skupine na površini mnogih mikroorganizama i aktivirati komplement u interakciji ...
BACKGROUND Respiratory infections are major causes of morbidity and mortality, but determinants of susceptibility are poorly defined. We studied whether and to what extent immunologic and genetic factors are associated with increased susceptibility to respiratory infections. METHODS We evaluated the prevalence of IgA, IgM, IgG, and IgG subclass deficiencies, impairment in the antibody respons...
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