Karst groundwater is the main water source for domestic, industrial, and agricultural needs in Xingtai City, North China. The objective of this study was to comprehensively access changes hydrochemical characteristics evolution karst response rapid urbanization. Water samples from late 2010s 1970s were compared utilizing statistical analysis, diagrams, inverse simulation technology. total disso...

Levothyroxine (T4) is a narrow therapeutic index drug with classic bioequivalence problem between various available products. Dissolution of a drug is a crucial step in its oral absorption and bioavailability. The dissolution of T4 from three commercial solid oral dosage forms: Synthroid (SYN), generic levothyroxine sodium by Sandoz Inc. (GEN) and Tirosint (TIR) was studied using a sensitive IC...

Amorphous solid dispersions (ASDs) have been extensively exploited as a strategy for improving the dissolution performance of poorly water-soluble drugs. However, factors underpinning the observed dissolution profiles are not clearly understood, and the choice of polymeric carriers is largely empirical. In the current study, the dissolution performance of a high drug loading ASD containing the ...

Groundwater vulnerability assessment is of crucial importance for land use/cover management. Some methods have been proposed specifically for the karst hydrogeological settings. Among them, COP and PaPRIKa, as two commonly applied recent methods, were adopted for the resource vulnerability assessment of a humid temperate karst region, north of Iran. Comparison of water bacterial content and dis...

Karst is a hydrogeological environment of importance not only for its water resources potential but also for its scenic and economic potential, thereby increasing the intensity of human impact. The uniqueness of karst in this regard stems from its high sensitivity and vulnerability to imposed pressures and its distinctive response to these pressures. Therefore, a clear definition and formulatio...