Motivated by the analysis of gene expression data, we develop a new unsupervised modeling technique. Specifically, we study how such data can be modeled via sparse matrix factorization (SMF). Unsupervised modeling using constrained matrix factorization has been studied by Lee and Seung [1, 2, 3]. Under this approach, one unveils structure in a data matrix A ∈ Rn×d, by approximating it as a prod...

Background & Objective: Mutations in embB306 gene and their association with resistance to ethambutol (EMB) in Mycobacterium tuberculosis (M. tuberculosis) have not been fully investigated. The aim of this study was to investigate the point-mutations in emb306B gene and their association with resistance to EMB in M. tuberculosis. Materials & Methods: This case (M. tuberculosis resistant to EMB...

We present a model and propose an approach to compute an approximate solution of Fully Fuzzy Linear System $(FFLS)$ of equations in which all the components of the coefficient matrix are either nonnegative or nonpositive. First, in discussing an $FFLS$ with a nonnegative coefficient matrix, we consider an equivalent $FFLS$ by using an appropriate permutation to simplify fuzzy multiplications. T...

Mycoplasma synoviae expressed variable lipoprotein haemagglutinin (VlhA) is believed to play a major role in pathogenesis of the disease by mediating adherence and immune evasion. The aim of this study was sequencing Iranian M. synoviae isolates for the detection of nucleotide variation in the M. synoviae vlhA gene. Using oligonucleotide primers complementary to the single-copy conserved 5´ end...

ABSTRACTTuberculosis is an infectious disease which occurs widely in the world and becomes one of the top 10 causes of death worldwide. Mutations of the RpoB gene cause the resistance of Mycobacterium tuberculosis to rifampicin that contributes to the occurrence of MDR-TB. This study aimed to determine the pattern of rpoB gene polymorphisms in the MDR M. tuberculosis in Semarang, Indonesia. Mos...

The nucleotide sequence of the gene encoding the matrix (M) protein of the Beaudette C strain of Newcastle disease virus (NDV) has been determined from overlapping cDNA clones. Control sequences typical of paramyxovirus mRNA start and polyadenylation signals have been identified. Assuming that the M gene starts and finishes at these sequences, the M gene is 1241 nucleotides long and encodes one...