BACKGROUND A causal relationship between maternal obesity and offspring asthma is hypothesized to begin during early development, but no underlying mechanism for the found association is identified. We quantitatively examined mediation by offspring body mass index (BMI) in the association of maternal pre-pregnancy BMI on risk of asthma and wheezing during the first 7-8 years of life in a large ...

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to m...

Understanding the experiences of a pragmatic lifestyle intervention for women with gestational diabetes mellitus and overweight/obesity to reduce maternal weight at 12 months postpartum - Volume 82 Issue OCE4

Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D). Exendin-4 (Exd-4) activates the glucagon like peptide-1 (GLP-1) receptor thereby decreasing serum glucose levels and body weight. In addition, Exd-4 has been shown to reduce renal and cardiac complications in experimental models of T2D. We hypothesized that treatment with Exd-...

Context Maternal hypertensive disorders during pregnancy are suggested to affect obesity risk in offspring. However, little is known about the prospective association of rise in maternal blood pressure within normal range during pregnancy with this risk for obesity. Objective To clarify the associations of diastolic and systolic blood pressure during pregnancy among normotensive women with th...

Risk of obesity in adult life is subject to programming during gestation. To examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition. Feeding liquid diets to adult female rats at 220 kcal/kg(3/4) per day (15% excess cal...

INTRODUCTION The objective of this study was to identify predictors of severe obesity in a low-income, predominantly Hispanic/Latino sample of children in Texas. METHODS This cross-sectional analysis examined baseline data on 517 children from the secondary prevention component of the Texas Childhood Obesity Research Demonstration (TX CORD) study; data were collected from September 2012 throu...

In recent years, the prevalence of obesity among UK women has increased substantially with 40% being overweight and 25% obese in 2010. In women of childbearing age, the excess body weight is of particular concern with obese parturients experiencing an increased incidence of complications compared with normal weight mothers. In addition to the maternal risks associated with excess body weight, f...

Children born to overweight and obese women, as compared to those of normal weight women, have greater risk for becoming obese themselves and suffering comorbid metabolic health problems. Evidence is accumulating that this increased susceptibility is at least partially attributed to a prenatal programming effect, whereby obesogenic factors in the intrauterine environment alter fetal development...

The prevalence of obesity is high and rising worldwide. The greatest prevalence of obesity is found in the western world and in urban developing countries. There is an increased maternal mortality associated with maternal obesity. There are increased risks of most maternal complications in pregnancy including pre-eclampsia, gestational and pre-existing type 2 diabetes mellitus and thromboemboli...