conclusions our findings showed that the treatment of flaps with bm-msc and aam transplantations significantly promoted flap survival compared to a control group. the viability of the flap was improved by combining bm-mscs with aam matrix scaffolds. materials and methods bm-mscs and aams were transplanted into subcutaneous tissue in the flap area. on the 7th postoperative day, the surviving fla...

background: previous investigations have revealed, cimetidine, a histamine h2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. in this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine h2-receptor antagonists, was investigated. materials and methods : balb/c m...

the relationship between the way in which normal hemopoietic stem cells respond to irradiation alone or in the presence of bleomycin sulfate (blm-s) and actinomycin 0 (act-d) was investigated. single doses of blm-s at 0.3 mg/kg and act-o at 0.10 mg/kg body weight were injected intravenously 1-6 hours prior to whole body irradiation and treatment was repeated twice more with time intervals. when...

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

osteoarthritis (oa) is a prevalent chronic disease impacting on quality of life and has societal and economical burden increasing with age. yet, no confirmed pharmacological, biological or surgical therapy could prevent the progressive destruction of oa joint. mesenchymal stem cells (mscs) with immunosuppressive activities emerged a potential therapy. we describe a magnetic resonance images (mr...

background:  infections  in  neutropenic  patients  are  considered  as  major  causes  of  mortality and the emergence of drug resistance. gram positive bacterial infections are crucially important to be covered if indicated. vancomycin is active against most gram positive bacteria including methicillin resistant staphylococcus aureus (mrsa). in this study, we evaluated the appropriate utiliza...

different types of actinomyces spp isolated from the oral cavity of human in healthy as well as in pathological state. internally it is only found in association with pathological organs. recently actinomyces naeslundii has been isolated from blood culture of a leukemic patient. present studies indicate the association of this microorganism with cells obtained from bone marrow by punction in mo...

introduction: silymarin is obtained from silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its a...

the wharton’s jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (mscs) which can be therapeutically applied in degenerative diseases. in this study, we investigated the immunomodulatory effect of umbilical cord derived- mesenchymal stem  cells (uc-mscs) and  bone  marrow-derived-mesenchymal stem  cells (bm-mscs) on differentiation, maturation, and endocytosis of m...